Midline and right frontal brain function as a physiologic biomarker of remission in major depression.
Midline and right frontal brain function as a physiologic biomarker of remission in major depression.
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DOI：
10.1016/j.pscychresns.2009.04.011
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发表时间：
2009-11-30
影响因子：
2.3
通讯作者：
Leuchter, Andrew F.
中科院分区：
文献类型：
--
作者：
Cook, Ian A.;Hunter, Aimee M.;Abrams, Michelle;Siegman, Barbara;Leuchter, Andrew F.
Prior investigations have reported that changes in the prefrontal electroencephalogram (EEG) precede symptom improvement from antidepressant medications, and could serve as a biomarker of treatment outcome in major depressive disorder (MDD). A new physiologically-defined region of interest, overlying the midline and right frontal (MRF) cortical area, was examined here for a relationship between early decreases in theta-band cordance and remission. Subjects were 72 adults with unipolar MDD who had completed placebo-controlled antidepressant treatment trials, with 37 randomized to medication and 35 to placebo. We assessed changes in cordance and absolute and relative power in the MRF region at 48 hours, 1 week, and 2 weeks after start of drug, as potential predictors of remission (final Ham-D17 ≤5). Eleven of 37 medication subjects (30%) remitted vs 6 of 35 placebo subjects (17%). Change in MRF cordance one and two weeks after start of drug was significantly associated with remission in medication subjects (P=0.02 at 1 week), with Receiver Operating Characteristic (ROC) analysis yielding 0.76 area under the curve. Decreases in MRF cordance at 1 week predicted remission with medication with 69% overall accuracy (90% sensitivity; 60% specificity). MRF cordance changes were not associated with remission with placebo. Absolute and relative power did not differentiate groups. These results suggest that remission may be predictable from physiologic measurements after 1 week of treatment, and that this region merits further investigation in the neurobiology of treatment response.
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影响因子：
4.8
作者：
Cook, IA;Leuchter, AF;Abrams, M
通讯作者：
Abrams, M
影响因子：
17.7
作者：
Hunter, Aimee M.;Leuchter, Andrew F.;Cook, Ian A.
通讯作者：
Cook, Ian A.
影响因子：
2.6
作者：
Gotlib, IH;Ranganath, C;Rosenfeld, JP
通讯作者：
Rosenfeld, JP
DOI：
10.1016/0013-4694(75)90056-5
发表时间：
1975-01-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
HJORTH, B
通讯作者：
HJORTH, B
影响因子：
1.7
作者：
Ishii, R;Shinosaki, K;Takeda, M
通讯作者：
Takeda, M