Factors that influence parental attitudes toward enrollment in type 1 diabetes trials.
Factors that influence parental attitudes toward enrollment in type 1 diabetes trials.
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DOI：
10.1371/journal.pone.0044341
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Moore DJ
中科院分区：
文献类型：
--
作者：
Buscariollo DL;Davidson MA;Black M;Russell WE;Rothman RL;Moore DJ
评估家长对 1 型糖尿病临床试验 (T1DCT) 的态度以及影响是否愿意让患有或未患有糖尿病的孩子入组的因素。在学术诊所和糖尿病教育活动中对 1 型糖尿病儿童的家长进行了一项横断面调查。调查回复率为36%。在 166 名参与家长中，76% 了解 T1DCT。与未受影响的儿童 (36%) 相比，更多的家长 (47%) 表示愿意招收糖尿病儿童。只有 18% 的人记得被要求让他们的孩子入学，而其中 60% 的人至少在某些时候同意入学。不到 30% 的人对安慰剂感到满意。预测是否愿意让患有糖尿病的儿童入组的因素包括医疗保健提供者的信任、对代理人同意的舒适度、对儿童成为“小白鼠”的恐惧程度以及对安慰剂的舒适度。预测是否愿意招募未受影响儿童的因素包括提供者的信任、对代理同意的舒适度、对安慰剂的舒适度以及理解 T1DCT 信息的难易程度。家长表示愿意让孩子参加 T1DCT。共同的试验方法会降低意愿。尽管大多数家长回忆起收到过与试验相关的信息，但回忆起被要求参加的家长要少得多。围绕家长关注的已确定领域优化有效沟通的努力可能会增加 T1DCT 的参与度。
To assess parental attitudes towards type 1 diabetes clinical trials (T1DCTs) and factors that impact willingness to enroll their children with and without diabetes. A cross-sectional survey of parents of children with type 1 diabetes was administered at an academic clinic and a diabetes educational event. Survey response rate was 36%. Of 166 participating parents, 76% were aware of T1DCTs. More parents reported willingness to enroll children with diabetes (47%) than unaffected children (36%). Only 18% recalled being asked to enroll their children, and of these, 60% agreed to enroll at least some of those times. Less than 30% were comfortable with placebos. Factors predicting willingness to enroll children with diabetes included healthcare provider trust, comfort with consent by proxy, low fear of child being a “guinea pig,” and comfort with placebo. Factors predicting willingness to enroll unaffected children were provider trust, comfort with consent by proxy, comfort with placebo, and perceived ease of understanding T1DCT information. Parents report moderate willingness to enroll children in T1DCTs. Willingness is diminished by common trial methodologies. Although most parents recalled receiving trial-related information, significantly fewer recalled being asked to participate. Efforts to optimize effective communication around identified areas of parental concern may increase T1DCT participation.
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