Outdoor Air Pollution and COPD-Related Emergency Department Visits, Hospital Admissions, and Mortality: A Meta-Analysis.
Outdoor Air Pollution and COPD-Related Emergency Department Visits, Hospital Admissions, and Mortality: A Meta-Analysis.
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DOI：
10.1080/15412555.2016.1216956
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发表时间：
2017-03
期刊：
影响因子：
2.2
通讯作者：
Sama S
中科院分区：
文献类型：
--
作者：
DeVries R;Kriebel D;Sama S
完成了一项系统性文献综述，以识别所有同行评审文献，这些文献量化了短期暴露于< 2.5微米（PM2.5）、二氧化氮（NO2）和二氧化硫（SO2）与COPD相关急诊（艾德）就诊、住院（HA）和死亡率之间的相关性。然后，通过随机效应模型的荟萃分析，对每种污染物的结果进行综合。探讨了亚组荟萃分析，以研究选定的滞后/平均时间和健康结果的影响。共有37项研究符合我们的纳入标准，为我们的荟萃估计提供了总计约1，115，000例COPD相关急性事件（950，000例HA，80，000例ED和130，000例死亡）。PM2.5增加10 ug/m3与COPD相关艾德和HA风险增加2.5%（95% CI：1.6%-3.4%）相关，NO2增加10 ug/m3与4.2%（2.5%-6.0%）相关，SO2增加10 ug/m3与2.1%（0.7%-3.5%）相关。然而，这些合并效应估计值的强度取决于暴露和结局之间选定的滞后/平均时间。对每种污染物和COPD相关死亡率估计了类似的合并效应。这些结果表明，户外颗粒物和气态污染物对COPD患者的健康构成持续威胁。室外环境中PM2.5、NO2和SO2浓度与COPD相关的发病率和死亡率显著正相关。
A systematic literature review was completed to identify all peer-reviewed literature quantifying the association between short-term exposures of particulate matter < 2.5 microns (PM2.5), nitrogen dioxide (NO2), and sulfur dioxide (SO2) and COPD-related emergency department (ED) visits, hospital admissions (HA), and mortality. These results were then synthesized for each pollutant through meta-analyses with a random effects model. Sub-group meta-analyses were explored to study the impacts of selected lag/averaging times and health outcomes. A total of 37 studies satisfied our inclusion criteria, contributing a total of approximately 1,115,000 COPD-related acute events (950,000 HAs, 80,000 EDs, and 130,000 deaths) to our meta-estimates. A 10 ug/m3 increase in PM2.5 was associated with a 2.5% (95% CI: 1.6%–3.4%) increased risk of COPD-related ED and HA, a 10 ug/m3 increase in NO2 was associated with a 4.2% (2.5%–6.0%) increase, and a 10 ug/m3 increase in SO2 was associated with a 2.1% (0.7%–3.5%) increase. The strength of these pooled effect estimates, however, varied depending on the selected lag/averaging time between exposure and outcome. Similar pooled effects were estimated for each pollutant and COPD-related mortality. These results suggest an ongoing threat to the health of COPD patients from both outdoor particulates and gaseous pollutants. Ambient outdoor concentrations of PM2.5, NO2, and SO2 were significantly and positively associated with both COPD-related morbidity and mortality.
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影响因子：
24.3
作者：
Fusco, D;Forastiere, F;Perucci, CA
通讯作者：
Perucci, CA
影响因子：
5.4
作者：
Faustini, Annunziata;Stafoggia, Massimo;Forastiere, Francesco
通讯作者：
Forastiere, Francesco
影响因子：
1.8
作者：
Cirera, L.;Garcia-Marcos, L.;Navarro, C.
通讯作者：
Navarro, C.
影响因子：
120.7
作者：
Dominici, F;Peng, RD;Samet, JM
通讯作者：
Samet, JM
影响因子：
6.3
作者：
Garcia-Aymerich, J;Tobías, A;Sunyer, J
通讯作者：
Sunyer, J