Extracellular vesicles as emerging intercellular communicasomes.
Extracellular vesicles as emerging intercellular communicasomes.
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DOI：
10.5483/bmbrep.2014.47.10.164
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发表时间：
2014-10
期刊：
影响因子：
3.8
通讯作者：
Gho YS
中科院分区：
文献类型：
--
作者：
Yoon YJ;Kim OY;Gho YS
所有活细胞释放的胞外囊泡在细胞间通讯中具有多效性。哺乳动物细胞外囊泡，也被称为外泌体和微囊泡，是由各种生物活性分子组成的球形双层蛋白质脂质，包括rna、dna、蛋白质和脂质。细胞外囊泡通过传递膜蛋白、信号分子、mrna和mirna以及激活受体细胞的受体，直接或间接地控制多种生物过程。细胞外囊泡与其他细胞的积极相互作用调节各种生理和病理状况，包括癌症、传染病和神经退行性疾病。高通量蛋白质组学、转录组学和脂质组学工具的最新发展为各种类型的细胞外囊泡的共同和特定成分提供了充足的数据。这些研究可能有助于理解囊泡货物分选和细胞外囊泡生物发生的分子机制，并进一步有助于识别疾病特异性生物标志物。本文就细胞外囊泡的组成、功能以及在各种病理生理条件下的治疗和诊断潜力作一综述。[BMB报告2014；47 (10): 531 - 539)
All living cells release extracellular vesicles having pleiotropic functions in intercellular communication. Mammalian extracellular vesicles, also known as exosomes and microvesicles, are spherical bilayered proteolipids composed of various bioactive molecules, including RNAs, DNAs, proteins, and lipids. Extracellular vesicles directly and indirectly control a diverse range of biological processes by transferring membrane proteins, signaling molecules, mRNAs, and miRNAs, and activating receptors of recipient cells. The active interaction of extracellular vesicles with other cells regulates various physiological and pathological conditions, including cancer, infectious diseases, and neurodegenerative disorders. Recent developments in high-throughput proteomics, transcriptomics, and lipidomics tools have provided ample data on the common and specific components of various types of extracellular vesicles. These studies may contribute to the understanding of the molecular mechanism involved in vesicular cargo sorting and the biogenesis of extracellular vesicles, and, further, to the identification of disease-specific biomarkers. This review focuses on the components, functions, and therapeutic and diagnostic potential of extracellular vesicles under various pathophysiological conditions. [BMB Reports 2014; 47(10): 531-539]
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影响因子：
4
作者：
Chivet M;Hemming F;Pernet-Gallay K;Fraboulet S;Sadoul R
通讯作者：
Sadoul R
DOI：
10.1111/tra.12016
发表时间：
2013-01
期刊：
Traffic (Copenhagen, Denmark)
影响因子：
--
作者：
Beckett K;Monier S;Palmer L;Alexandre C;Green H;Bonneil E;Raposo G;Thibault P;Le Borgne R;Vincent JP
通讯作者：
Vincent JP
影响因子：
11.2
作者：
Bobrie, Angelique;Krumeich, Sophie;Thery, Clotilde
通讯作者：
Thery, Clotilde
影响因子：
20.3
作者：
Deregibus, Maria Chiara;Cantaluppi, Vincenzo;Camussi, Giovanni
通讯作者：
Camussi, Giovanni
影响因子：
4.8
作者：
Bakhti, Mostafa;Winter, Christine;Simons, Mikael
通讯作者：
Simons, Mikael