Circulating Ki-67 index in plasma as a biomarker and prognostic indicator in chronic lymphocytic leukemia.
Circulating Ki-67 index in plasma as a biomarker and prognostic indicator in chronic lymphocytic leukemia.
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DOI：
10.1016/j.leukres.2010.03.010
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发表时间：
2010-10
影响因子：
2.7
通讯作者：
Albitar M
中科院分区：
文献类型：
--
作者：
Bruey JM;Kantarjian H;Ma W;Estrov Z;Yeh C;Donahue A;Sanders H;O'Brien S;Keating M;Albitar M
Ki-67是一种在细胞周期的所有阶段（G 0期除外）表达的核抗原，广泛用作人类肿瘤细胞增殖的标志物。我们最近发现，血浆中Ki-67循环（cKi-67）水平升高与急性淋巴细胞白血病患者生存期缩短相关。该研究包括194名CLL患者和96名健康对照受试者。使用电致发光免疫测定法测定血浆中的cKi-67水平。我们将cKI-67水平标准化为患者外周血中淋巴细胞的绝对数量，以建立血浆cKI-67指数。cKi-67指数与淋巴结转移和Rai分期相关（P = 0.05）。较高的cKi-67指数值与较短的生存期显著相关。多变量考克斯比例风险回归分析显示cKi-67指数与较短生存期的相关性与IgVH突变状态无关。在将cKi-67指数与B2 M和IgVH合并的多变量模型中，仅cKi-67指数和B2 M水平仍是生存的独立预测因子。本研究的结果表明，血浆cKi-67指数，沿着B2 M水平，是CLL临床行为的强预测因子
Ki-67 is a nuclear antigen that is expressed in all stages of the cell cycle, except G0, and is widely used as a marker of cellular proliferation in human tumors. We recently showed that elevated levels of Ki-67 circulating in plasma (cKi-67) are associated with shorter survival in patients with acute lymphoblastic leukemia. The study included 194 patients with CLL and 96 healthy control subjects. cKi-67 levels in plasma were determined using an electrochemiluminescent immunoassay. We normalized the cKi-67 level to the absolute number of lymphocytes in the patient's peripheral blood to establish the plasma cKI-67 index. The cKi-67 index showed significant correlation with lymph node involvement and Rai stage (P = 0.05). Higher cKi-67 index values were significantly associated with shorter survival. Multivariate Cox proportional hazards regression analysis demonstrated that the association of the cKi-67 index with shorter survival was independent of IgVH mutation status. In a multivariate model incorporating the cKi-67 index with B2M and IgVH, only cKi-67 index and B2M levels remained as independent predictors of survival. The results of this study suggest that the plasma cKi-67 index, along with B2M level, is a strong predictor of clinical behavior in CLL
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