Spiking neurons that keep the rhythm
Spiking neurons that keep the rhythm
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保持节律的尖峰神经元
DOI：
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发表时间：
2011
影响因子：
1.2
通讯作者：
P. Cisek
中科院分区：
文献类型：
--
作者：
J. Thivierge;P. Cisek
检测环境中事件之间的时间关系是大脑的基本目标。在有节奏的刺激脉冲之后，视网膜和皮层的神经元产生的活动非常接近被忽略的脉冲的时间。这种省略的刺激反应（OSR）通常被解释为对节奏输入的瞬态反应，并被认为是形成短期感知记忆的基础。尽管它在物种和实验方案中无处不在，但OSR的潜在机制仍然知之甚少。特别是，OSR的高度瞬态性质（通常限于刺激后的单个周期）无法通过将保持锁定到刺激频率的简单机制来解释。在这里，我们描述了一组逼真的模拟，捕捉OSR在一系列的刺激频率匹配的实验工作。该模型不需要一个明确的机制来学习时间序列。相反，它依赖于尖峰时间依赖性可塑性（STDP），这是一种对突触前和突触后动作电位的时间敏感的突触修饰形式。在该模型中，OSR的瞬态性质归因于神经特性和连接的异质性，从而产生了随时间不断变化的复杂活动形式。结合STDP，神经异质性使OSR复杂的节奏模式，以及OSR后的延迟期。这些结果将神经元对节律模式的反应与异质回路产生短暂和高度灵活形式的神经活动的能力联系起来。
Detecting the temporal relationship among events in the environment is a fundamental goal of the brain. Following pulses of rhythmic stimuli, neurons of the retina and cortex produce activity that closely approximates the timing of an omitted pulse. This omitted stimulus response (OSR) is generally interpreted as a transient response to rhythmic input and is thought to form a basis of short-term perceptual memories. Despite its ubiquity across species and experimental protocols, the mechanisms underlying OSRs remain poorly understood. In particular, the highly transient nature of OSRs, typically limited to a single cycle after stimulation, cannot be explained by a simple mechanism that would remain locked to the frequency of stimulation. Here, we describe a set of realistic simulations that capture OSRs over a range of stimulation frequencies matching experimental work. The model does not require an explicit mechanism for learning temporal sequences. Instead, it relies on spike timing-dependent plasticity (STDP), a form of synaptic modification that is sensitive to the timing of pre- and post-synaptic action potentials. In the model, the transient nature of OSRs is attributed to the heterogeneous nature of neural properties and connections, creating intricate forms of activity that are continuously changing over time. Combined with STDP, neural heterogeneity enabled OSRs to complex rhythmic patterns as well as OSRs following a delay period. These results link the response of neurons to rhythmic patterns with the capacity of heterogeneous circuits to produce transient and highly flexible forms of neural activity.
影响因子：
3.7
作者：
Abbott, LF;Blum, KI
通讯作者：
Blum, KI
DOI：
10.1073/pnas.0502332102
发表时间：
2005-07-05
影响因子：
11.1
作者：
O'Connor, DH;Wittenberg, GM;Wang, SSH
通讯作者：
Wang, SSH
DOI：
10.1073/pnas.0303760101
发表时间：
2004-04-27
影响因子：
11.1
作者：
Jääskeläinen, IP;Ahveninen, J;Belliveau, JW
通讯作者：
Belliveau, JW