Behavioral and neuroanatomical effects of prenatal, postnatal, or combined exposure to ethanol in weanling rats.
Behavioral and neuroanatomical effects of prenatal, postnatal, or combined exposure to ethanol in weanling rats.
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断奶大鼠产前、产后或联合接触乙醇对行为和神经解剖学的影响。
DOI：
10.1037//0735-7044.104.1.116
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发表时间：
1990
影响因子：
1.9
通讯作者：
A. Amsel
中科院分区：
文献类型：
--
作者：
Tim Wigal;A. Amsel
出生前和出生后暴露于乙醇的活动，情绪，学习和海马神经解剖的单独和综合影响进行了研究。在妊娠第1-21天（G）喂食液体乙醇（E）或对照（C）饮食的母亲的新生大鼠在产后第4-12天（P）在3%乙醇（E）或等热量麦芽糖/糊精（C）中人工饲养。配方奶粉。在P19时，在开放视野中测试这些处理组（EE、EC、CE和CC）中的幼仔的活动和情绪，在P20-P21时测试食欲、直接失控任务的获得和消退，以及在P21时测试乙醇处理对海马神经解剖学改变的影响。活动和情绪上的差异很小。乙醇既影响部分强化的获得效应，也影响部分强化的消退效应。海马细胞密度（与CC组相比）显示，EC组和EE组中CA 1锥体细胞减少12%，成熟颗粒细胞减少11%;出生后暴露（CE组和EE组）后，CA 4面积（与CC组相比）显著增大。CC组和CE组部分强化训练后消退率与CA 1区锥体细胞密度呈显著正相关。EE组的消退率与CA 4区面积呈显著负相关。
Separate and combined effects of prenatal and postnatal exposure to ethanol on activity, emotionality, learning, and hippocampal neuroanatomy were examined in infant rats. Neonatal rats from mothers that were fed either a liquid ethanol (E) or control (C) diet on Gestational Days (G) 1-21 were artificially reared during Postnatal Days (P) 4-12 on either 3% ethanol (E) or isocaloric maltose/dextrin (C) in a milk formula. Pups in these treatment groups (EE, EC, CE, and CC) were tested for activity and emotionally in an open field on P19, for acquisition and extinction of an appetitive, straight runaway task on P20-P21, and for the effects of ethanol treatments on alterations in hippocampal neuroanatomy on P21. Differences in activity and emotionally were slight. Ethanol affected both the partial reinforcement acquisition effect and the partial reinforcement extinction effect. Hippocampal cell density (compared with Group CC) showed a 12% reduction in CA1 pyramidal cells and an 11% reduction in mature granule cells in Groups EC and EE; the CA4 area (compared with Group CC) was significantly larger after postnatal exposure (Groups CE and EE). Significant positive correlations were found between rate of extinction after partial reinforcement (PRF) training and CA1 pyramidal cell density in Groups CC and CE. A significant negative correlation was found between extinction rate after PRF training and CA4 area in Group EE.
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产后酒精引起的区域大脑生长的差异性缺陷。
影响因子：
2.9
作者：
Pierce,DR;West,JR
通讯作者：
West,JR
产前接触酒精的大鼠的低头行为与测试时年龄的关系。
DOI：
--
发表时间：
1983
期刊：
Neurobehavioral toxicology and teratology
影响因子：
--
作者：
Plonsky,M;Riley,EP
通讯作者：
Riley,EP
酒精与大脑发育。
DOI：
--
发表时间：
1987
期刊：
NIDA research monograph
影响因子：
--
作者：
West,JR;Goodlett,CR;Kelly,SJ
通讯作者：
Kelly,SJ
DOI：
--
发表时间：
1986
期刊：
Neurobehavioral toxicology and teratology
影响因子：
--
作者：
Abel,EL;Sokol,RJ
通讯作者：
Sokol,RJ
妊娠晚期乙醇暴露对大鼠海马和齿状回神经元数量的影响。
DOI：
10.1111/j.1530-0277.1986.tb05070.x
发表时间：
1986
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
West,JR;Hamre,KM;Cassell,MD
通讯作者：
Cassell,MD