Weight management intervention identifies association of decreased DNA methylation age with improved functional age measures in older adults with obesity.
Weight management intervention identifies association of decreased DNA methylation age with improved functional age measures in older adults with obesity.
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DOI：
10.1186/s13148-021-01031-7
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发表时间：
2021-03-02
影响因子：
5.7
通讯作者：
Batsis JA
中科院分区：
文献类型：
--
作者：
Petersen CL;Christensen BC;Batsis JA
评估功能能力是了解健康老龄化的重要组成部分。功能能力的客观测量包括握力、步态速度、坐立时间和 6 分钟步行距离。我们使用肥胖老年人减肥临床试验的样本，研究了 16 名个体在基线和 12 周时身体机能变化与基于 DNA 甲基化的生物年龄之间的关联。使用 Illumina HumanMmethylationEPIC 阵列（前/后）测量外周血 DNA 甲基化，并使用 Hannum、Horvath 和 PhenoAge DNA 甲基化年龄时钟。根据实际年龄和性别进行调整的线性回归模型测试了 DNA 甲基化年龄与握力、步态速度、从坐到站和 6 分钟步行之间的关系。使用 Hannum、Horvath 和 PhenoAge DNA 甲基化时钟，参与者平均体重减轻 4.6 公斤，DNA 甲基化年龄分别减少 0.8、1.1 和 0.5 年。平均握力增加 3.2 公斤。在调整后的模型中，Hannum 甲基化年龄的降低与握力的增加（β = −0.30，p = 0.04）和步态速度的增加（β = 0.02，p = 0.05）显着相关。同样，使用 PhenoAge 时钟降低甲基化年龄与显着增加的步态速度相关（β = 0.02，p = 0.04）。 Horvath DNA 甲基化年龄的降低和身体功能能力的提高并未显示出显着的关联。使用 DNA 甲基化时钟观察到的身体功能能力增加和生物年龄降低之间的关系证明了 DNA 甲基化时钟在评估改善老年肥胖成年人健康的干预方法方面的潜在效用。试验注册：国家老龄化研究所（NIA），NCT03104192。发布于 2017 年 4 月 7 日，https://clinicaltrials.gov/ct2/show/NCT03104192
Assessing functional ability is an important component of understanding healthy aging. Objective measures of functional ability include grip strength, gait speed, sit-to-stand time, and 6-min walk distance. Using samples from a weight loss clinical trial in older adults with obesity, we examined the association between changes in physical function and DNA-methylation-based biological age at baseline and 12 weeks in 16 individuals. Peripheral blood DNA methylation was measured (pre/post) with the Illumina HumanMethylationEPIC array and the Hannum, Horvath, and PhenoAge DNA methylation age clocks were used. Linear regression models adjusted for chronological age and sex tested the relationship between DNA methylation age and grip strength, gait speed, sit-to-stand, and 6-min walk. Participant mean weight loss was 4.6 kg, and DNA methylation age decreased 0.8, 1.1, and 0.5 years using the Hannum, Horvath, and PhenoAge DNA methylation clocks respectively. Mean grip strength increased 3.2 kg. Decreased Hannum methylation age was significantly associated with increased grip strength (β = −0.30, p = 0.04), and increased gait speed (β = 0.02, p = 0.05), in adjusted models. Similarly, decreased methylation age using the PhenoAge clock was associated with significantly increased gait speed (β = 0.02, p = 0.04). A decrease in Horvath DNA methylation age and increase in physical functional ability did not demonstrate a significant association. The observed relationship between increased physical functional ability and decreased biological age using DNA methylation clocks demonstrate the potential utility of DNA methylation clocks to assess interventional approaches to improve health in older obese adults. Trial registration: National Institute on Aging (NIA), NCT03104192. Posted April 7, 2017, https://clinicaltrials.gov/ct2/show/NCT03104192
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影响因子：
4.5
作者：
Christensen BC;Houseman EA;Marsit CJ;Zheng S;Wrensch MR;Wiemels JL;Nelson HH;Karagas MR;Padbury JF;Bueno R;Sugarbaker DJ;Yeh RF;Wiencke JK;Kelsey KT
通讯作者：
Kelsey KT
全基因组甲基化谱揭示了人类衰老速度的定量观点。
影响因子：
16
作者：
Hannum, Gregory;Guinney, Justin;Zhao, Ling;Zhang, Li;Hughes, Guy;Sadda, SriniVas;Klotzle, Brandy;Bibikova, Marina;Fan, Jian-Bing;Gao, Yuan;Deconde, Rob;Chen, Menzies;Rajapakse, Indika;Friend, Stephen;Ideker, Trey;Zhang, Kang
通讯作者：
Zhang, Kang
DOI：
10.18632/aging.101414
发表时间：
2018-04-18
期刊：
Aging
影响因子：
--
作者：
Levine ME;Lu AT;Quach A;Chen BH;Assimes TL;Bandinelli S;Hou L;Baccarelli AA;Stewart JD;Li Y;Whitsel EA;Wilson JG;Reiner AP;Aviv A;Lohman K;Liu Y;Ferrucci L;Horvath S
通讯作者：
Horvath S
影响因子：
--
作者：
Jura, Magdalena;Kozak, Leslie. P.
通讯作者：
Kozak, Leslie. P.
影响因子：
12.3
作者：
Horvath S
通讯作者：
Horvath S