Multimodality molecular imaging: Gaining insights into the mechanisms linking chronic stress to cardiovascular disease.
Multimodality molecular imaging: Gaining insights into the mechanisms linking chronic stress to cardiovascular disease.
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多模态分子成像：深入了解慢性应激与心血管疾病的联系机制。
DOI：
10.1007/s12350-020-02424-6
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Tawakol A
中科院分区：
文献类型：
--
作者：
Osborne MT;Abohashem S;Zureigat H;Abbasi TA;Tawakol A
正电子发射断层扫描（PET）成像可以产生独特的机制洞察动脉粥样硬化的病理生理学。18 F-氟脱氧葡萄糖（18 F-FDG）是一种放射性标记的葡萄糖类似物，其被细胞保留的程度与其糖酵解活性成正比。虽然18F-FDG在动脉壁的几种细胞类型中积累，但其保留与巨噬细胞含量相关，提供了预测随后心血管疾病（CVD）事件的动脉炎症指数（阿尔蒂）。此外，18F-FDG-PET成像允许同时评估几种组织中的代谢活性（例如，脑、骨髓），并与能够进行多器官结构评估的横截面成像结合进行。因此，18F-FDG-PET/计算机断层扫描（CT）成像有助于评估跨越多个器官系统的疾病途径。在这种模式下，18F-FDG-PET/CT成像已被实施，以研究慢性应激与CVD的联系机制。为了评估这一点，可以量化与应激相关的神经活动（作为杏仁核（AmygA）的代谢活性），同时评估白细胞生成活性、阿尔蒂和冠状动脉斑块负荷。组织结构和活动的这种同时定量使得能够在中介分析的帮助下评估多器官通路。使用这种方法，多系统18F-FDG-PET/CT成像研究已经证明，慢性应激相关的神经生物学活性升高会促进白细胞生成活性和全身炎症。这反过来又增加了更多的阿尔蒂和更大的非钙化冠状动脉斑块负担，导致更多的CVD事件。随后的研究表明，常见的压力源，如慢性噪音暴露和收入差距，推动了这一途径的前端增加心血管疾病的风险。因此，多组织多模态成像作为一个强大的工具来揭示复杂的疾病机制。
Positron emission tomography (PET) imaging can yield unique mechanistic insights into the pathophysiology of atherosclerosis. 18F-fluorodeoxyglucose (18F-FDG), a radiolabeled glucose analog, is retained by cells in proportion to their glycolytic activity. While 18F-FDG accumulates within several cell types in the arterial wall, its retention correlates with macrophage content, providing an index of arterial inflammation (ArtI) which predicts subsequent cardiovascular disease (CVD) events. Furthermore, 18F-FDG-PET imaging allows the simultaneous assessment of metabolic activity in several tissues (e.g., brain, bone marrow) and is performed in conjunction with cross-sectional imaging that enables multi-organ structural assessments. Accordingly, 18F-FDG-PET/computed tomography (CT) imaging facilitates evaluation of disease pathways that span multiple organ systems. Within this paradigm, 18F-FDG-PET/CT imaging has been implemented to study the mechanism linking chronic stress to CVD. To evaluate this, stress-associated neural activity can be quantified (as metabolic activity of the amygdala (AmygA)), while leukopoietic activity, ArtI, and coronary plaque burden are assessed concurrently. Such simultaneous quantification of tissue structures and activities enables the evaluation of multi-organ pathways with the aid of mediation analysis. Using this approach, multi-system 18F-FDG-PET/CT imaging studies have demonstrated that chronically heightened stress-associated neurobiological activity promotes leukopoietic activity and systemic inflammation. This in turn fuels more ArtI and greater non-calcified coronary plaque burden, which result in more CVD events. Subsequent studies have revealed that common stressors, such as chronic noise exposure and income disparities, drive the front end of this pathway to increase CVD risk. Hence, multi-tissue multimodality imaging serves as a powerful tool to uncover complex disease mechanisms.
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DOI：
10.1001/jama.2016.4226
发表时间：
2016-04-26
期刊：
JAMA
影响因子：
--
作者：
Chetty R;Stepner M;Abraham S;Lin S;Scuderi B;Turner N;Bergeron A;Cutler D
通讯作者：
Cutler D
影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
37.8
作者：
Blumenthal JA;Sherwood A;Smith PJ;Watkins L;Mabe S;Kraus WE;Ingle K;Miller P;Hinderliter A
通讯作者：
Hinderliter A
影响因子：
34.7
作者：
Arnsten, Amy F. T.
通讯作者：
Arnsten, Amy F. T.
DOI：
10.1016/j.ejvs.2008.11.018
发表时间：
2009-06-01
影响因子：
5.7
作者：
Graebe, M.;Pedersen, S. F.;Kjaer, A.
通讯作者：
Kjaer, A.