Numerical modeling of long bone adaptation due to mechanical loading: correlation with experiments.
Numerical modeling of long bone adaptation due to mechanical loading: correlation with experiments.
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由于机械载荷而导致的长骨适应的数值模型：与实验相关。
DOI：
10.1007/s10439-009-9861-4
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发表时间：
2010-03
影响因子：
3.8
通讯作者：
Turner, Charles H.
中科院分区：
文献类型：
--
作者：
Kumar, Natarajan Chennimalai;Dantzig, Jonathan A.;Jasiuk, Iwona M.;Robling, Alex G.;Turner, Charles H.
使用有限元（FE）应力分析结合进化模型，在皮质骨中的外部骨适应过程的数学建模，其中适应响应由应变能密度表示的机械刺激触发。该模型应用于实验中，大鼠尺骨受到循环载荷，结果表明该模型预测骨适应反应的能力。从大鼠尺骨的微计算机断层扫描（μCT）图像生成FE网格，并使用从实验中获得的大鼠尺骨上的边界和载荷条件进行应力分析[Robling，A. G.，F. M. Hinant，D. B。Burr和C. H.特纳J.骨矿工。17：1545-1554，2002]。外部自适应过程是通过移动的FE网格的表面节点的基础上的演化规律，其特征在于两个参数的模型中实现的：一个捕获的自适应过程的速率（称为增益）;和其他特征的阈值所需的机械刺激的适应（称为阈值灵敏度）。进行参数研究，以评估这两个参数的适应反应的效果。我们表明，以下比较的结果从模拟的实验观察Robling等。（J.骨矿工。Res. 17：1545-1554，2002），将加载循环分成不同数量的回合影响阈值灵敏度，但不影响适应速率。我们还表明，阈值敏感性参数可以量化骨细胞的机械敏感性。
The process of external bone adaptation in cortical bone is modeled mathematically using finite element (FE) stress analysis coupled with an evolution model, in which adaptation response is triggered by mechanical stimulus represented by strain energy density. The model is applied to experiments in which a rat ulna is subjected to cyclic loading, and the results demonstrate the ability of the model to predict the bone adaptation response. The FE mesh is generated from micro-computed tomography (μCT) images of the rat ulna, and the stress analysis is carried out using boundary and loading conditions on the rat ulna obtained from the experiments [Robling, A. G., F. M. Hinant, D. B. Burr, and C. H. Turner. J. Bone Miner. Res. 17:1545–1554, 2002]. The external adaptation process is implemented in the model by moving the surface nodes of the FE mesh based on an evolution law characterized by two parameters: one that captures the rate of the adaptation process (referred to as gain); and the other characterizing the threshold value of the mechanical stimulus required for adaptation (referred to as threshold-sensitivity). A parametric study is carried out to evaluate the effect of these two parameters on the adaptation response. We show, following comparison of results from the simulations to the experimental observations of Robling et al. (J. Bone Miner. Res. 17:1545–1554, 2002), that splitting the loading cycles into different number of bouts affects the threshold-sensitivity but not the rate of adaptation. We also show that the threshold-sensitivity parameter can quantify the mechanosensitivity of the osteocytes.
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影响因子：
2.8
作者：
BEAUPRE, GS;ORR, TE;CARTER, DR
通讯作者：
CARTER, DR
影响因子：
6.2
作者：
Hsieh, YF;Turner, CH
通讯作者：
Turner, CH
影响因子：
6.2
作者：
Robling, AG;Hinant, FM;Turner, CH
通讯作者：
Turner, CH
影响因子：
--
作者：
FROST, HM
通讯作者：
FROST, HM
影响因子：
2.4
作者：
HUISKES, R;WEINANS, H;SLOOFF, TJ
通讯作者：
SLOOFF, TJ