Endogenous retinoids in the pathogenesis of alopecia areata.
Endogenous retinoids in the pathogenesis of alopecia areata.
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DOI：
10.1038/jid.2012.344
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发表时间：
2013-02
影响因子：
6.5
通讯作者：
Everts, Helen B.
中科院分区：
文献类型：
--
作者：
Duncan, F. Jason;Silva, Kathleen A.;Johnson, Charles J.;King, Benjamin L.;Szatkiewicz, Jin P.;Kamdar, Sonya P.;Ong, David E.;Napoli, Joseph L.;Wang, Jinshan;King, Lloyd E., Jr.;Whiting, David A.;McElwee, Kevin J.;Sundberg, John P.;Everts, Helen B.
斑秃(AA)是一种攻击生发毛囊的自身免疫性疾病。C3H/HeJ小鼠移植模型的基因芯片显示，与假手术对照组相比，与维甲酸(RA)合成相关的基因增加，RA降解基因减少。免疫组织化学证实了这一点，来自AA患者以及小鼠和大鼠AA模型的活检组织。再障C3H/HeJ小鼠体内RA水平也明显升高。在移植前两周，C3H/HeJ小鼠被喂以含有四种维生素A水平之一的纯化饲料或未纯化饲料，随后疾病进展。高维生素A会加速再生障碍性贫血，而不喂食维生素A的小鼠在研究结束时会患上更严重的疾病。高维生素A可改变颗粒酶B阳性细胞的数量和分布，高维生素A组IFNG最低，IL13最高，其他细胞因子随病情进展而减少，趋化因子增加，但维生素A未见额外作用。总而言之，这些结果表明，维生素A调节头发周期和免疫反应，以改变再生障碍性贫血的进展。
Alopecia areata (AA) is an autoimmune disease that attacks anagen hair follicles. Gene array in graft-induced C3H/HeJ mice revealed that genes involved in retinoic acid (RA) synthesis were increased, while RA degradation genes were decreased in AA compared to sham controls. This was confirmed by immunohistochemistry in biopsies from patients with AA and both mouse and rat AA models. RA levels were also increased in C3H/HeJ mice with AA. C3H/HeJ mice were fed a purified diet containing one of four levels of dietary vitamin A or an unpurified diet two weeks before grafting and disease progression followed. High vitamin A accelerated AA, while mice fed no vitamin A had more severe disease by the end of the study. More hair follicles were in anagen in mice fed high vitamin A. Both the number and localization of granzyme B positive cells were altered by vitamin A. IFNG was also lowest and IL13 highest in mice fed high vitamin A. Other cytokines were reduced and chemokines increased as the disease progressed, but no additional effects of vitamin A were seen. Combined, these results suggest that vitamin A regulates both the hair cycle and immune response to alter the progression of AA.
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DOI：
10.1084/jem.20071966
发表时间：
2007-12-24
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bursch LS;Wang L;Igyarto B;Kissenpfennig A;Malissen B;Kaplan DH;Hogquist KA
通讯作者：
Hogquist KA
白介素10在抑制肠炎的调节T细胞功能中的重要作用。
影响因子：
15.3
作者：
Asseman, C;Mauze, S;Leach, M W;Coffman, R L;Powrie, F
通讯作者：
Powrie, F
影响因子：
6.5
作者：
Everts, Helen B.;Sundberg, John P.;Ong, David E.
通讯作者：
Ong, David E.
影响因子：
4.2
作者：
ANZANO, MA;LAMB, AJ;OLSON, JA
通讯作者：
OLSON, JA
DOI：
10.1158/1940-6207.capr-08-0193
发表时间：
2009-07
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Duncan FJ;Martin JR;Wulff BC;Stoner GD;Tober KL;Oberyszyn TM;Kusewitt DF;Van Buskirk AM
通讯作者：
Van Buskirk AM