Turning on the Radio: Epigenetic Inhibitors as Potential Radiopriming Agents.
Turning on the Radio: Epigenetic Inhibitors as Potential Radiopriming Agents.
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DOI：
10.3390/biom6030032
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发表时间：
2016-07-04
期刊：
影响因子：
5.5
通讯作者：
Oronsky A
中科院分区：
文献类型：
--
作者：
Oronsky B;Scicinski J;Kim MM;Cabrales P;Salacz ME;Carter CA;Oronsky N;Lybeck H;Lybeck M;Larson C;Reid TR;Oronsky A
放射疗法于19世纪后期首次引入，是癌症治疗的基础。在发达国家，大约60%的患者接受放射治疗（也称为60%），这使得癌症的放射耐药性成为一个重要的，迄今为止尚未解决的临床问题。不幸的是，实体瘤的治疗难治性是规律而非例外，而且普遍存在的耐药性也延伸到标准化疗、分子靶向治疗和免疫治疗。根据最近使用表观遗传药物治疗难治性肿瘤的临床进展推断，放射耐药表型可能是可逆的，因为异常的表观遗传机制是恶性细胞耐药亚群进化的关键因素。在三段论的框架内，本综述探讨了表观遗传学与放射抗性发展之间的新联系，并提出了与表观遗传学药物预先或共同治疗的策略，不仅可以抑制不适当沉默的基因，还可以增加活性氧的产生，从而恢复放射敏感性。
First introduced during the late 1800s, radiation therapy is fundamental to the treatment of cancer. In developed countries, approximately 60% of all patients receive radiation therapy (also known as the sixty percenters), which makes radioresistance in cancer an important and, to date, unsolved, clinical problem. Unfortunately, the therapeutic refractoriness of solid tumors is the rule not the exception, and the ubiquity of resistance also extends to standard chemotherapy, molecularly targeted therapy and immunotherapy. Based on extrapolation from recent clinical inroads with epigenetic agents to prime refractory tumors for maximum sensitivity to concurrent or subsequent therapies, the radioresistant phenotype is potentially reversible, since aberrant epigenetic mechanisms are critical contributors to the evolution of resistant subpopulations of malignant cells. Within the framework of a syllogism, this review explores the emerging link between epigenetics and the development of radioresistance and makes the case that a strategy of pre- or co-treatment with epigenetic agents has the potential to, not only derepress inappropriately silenced genes, but also increase reactive oxygen species production, resulting in the restoration of radiosensitivity.
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DOI：
10.1038/nrclinonc.2013.42
发表时间：
2013-05
期刊：
Nature reviews. Clinical oncology
影响因子：
--
作者：
通讯作者：
--
影响因子：
78.5
作者：
Issa, JP
通讯作者：
Issa, JP
影响因子：
64.5
作者：
Goldberg, Aaron D.;Allis, C. David;Bernstein, Emily
通讯作者：
Bernstein, Emily
影响因子：
4.8
作者：
Fath, DM;Kong, XG;Sang, NL
通讯作者：
Sang, NL
影响因子：
5.8
作者：
Buchholz, TA;Strom, EA;McNeese, MD
通讯作者：
McNeese, MD