The Link between APOE4 Presence and Neuropsychological Test Performance among Mexican Americans and Non-Hispanic Whites of the Multiethnic Health & Aging Brain Study - Health Disparities Cohort.
The Link between APOE4 Presence and Neuropsychological Test Performance among Mexican Americans and Non-Hispanic Whites of the Multiethnic Health & Aging Brain Study - Health Disparities Cohort.
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DOI：
10.1159/000521898
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发表时间：
2022
影响因子：
2.4
通讯作者：
中科院分区：
文献类型：
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作者：
The APOEε4 allele is the single strongest genetic risk for late-onset Alzheimer’s disease (AD). Prior work demonstrates that not only the APOEε4 allele varies by race/ethnicity but also the risk for AD and cognitive impairment conveyed by the APOEε4 allele varies by the racial/ethnic group as well as genetic ancestry. Here, we sought to examine the link between the APOEε4 and neuropsychological functioning among Mexican Americans (MAs). Data were examined from 1,633 (852 MAs and 781 non-Hispanic Whites [NHWs]) participants of the Health & Aging Brain Study – Health Disparities (HABS-HD) and were enrolled with all requisite data to be included into the current analyses. The frequency of both ε4 and ε2 alleles was significantly lower among MAs as compared to NHWs. Among MAs, APOEε4 allele presence was associated specifically with poorer immediate and delayed memory (Wechsler Memory Scale – Third Edition [WMS-III] Logical Memory and Spanish-English Verbal Learning Test [SEVLT]). Among NHWs, APOEε4 allele presence was associated with poorer immediate and delayed memory as well as worse executive functioning (Trials B) and verbal fluency (Animal naming). The APOEε4 allele was associated with poorer cognition across multiple domains among NHWs; however, allele presence was specifically associated with poorer memory performance among MAs. When combined with prior work, the current findings demonstrate that the risk factors associated with cognitive dysfunction differ among MAs as compared to NHWs and require additional investigation.
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影响因子：
4.5
作者：
Rajabli, Farid;Feliciano, Briseida E.;Pericak-Vance, Margaret A.
通讯作者：
Pericak-Vance, Margaret A.
影响因子：
3.9
作者：
González, HM;Mungas, D;Haan, MN
通讯作者：
Haan, MN
影响因子：
120.7
作者：
Tang, MX;Stern, Y;Mayeux, R
通讯作者：
Mayeux, R
DOI：
10.1002/alz.12287
发表时间：
2021-07
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Griswold AJ;Celis K;Bussies PL;Rajabli F;Whitehead PL;Hamilton-Nelson KL;Beecham GW;Dykxhoorn DM;Nuytemans K;Wang L;Gardner OK;Dorfsman DA;Bigio EH;Mesulam MM;Weintraub S;Geula C;Gearing M;McGrath-Martinez E;Dalgard CL;Scott WK;Haines JL;Pericak-Vance MA;Young JI;Vance JM
通讯作者：
Vance JM
DOI：
10.3233/jad-2012-121420
发表时间：
2013
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
O'Bryant SE;Johnson L;Balldin V;Edwards M;Barber R;Williams B;Devous M;Cushings B;Knebl J;Hall J
通讯作者：
Hall J