Transmitters, membrane properties and network circuitry in the control of locomotion in lamprey
Transmitters, membrane properties and network circuitry in the control of locomotion in lamprey
复制标题
七鳃鳗运动控制中的发射器、膜特性和网络电路
DOI：
10.1016/0166-2236(87)90123-8
复制
发表时间：
1987
影响因子：
15.9
通讯作者：
R. Hill
中科院分区：
文献类型：
--
作者：
S. Grillner;P. Wallén;N. Dale;L. Brodin;J. Buchanan;R. Hill
七鳃鳗的脑干和脊髓可以在体外维持。它是一种简单的脊椎动物制剂，具有相对较少的神经元。不同行为模式的神经关联可以在这种体外制备中被激发出来。本综述的主题是运动背后的神经元组织，特别是不同类型的中间神经元及其递质和突触相互作用模式的作用。兴奋性氨基酸、甘氨酸、GABA、5-羟色胺、快激肽和CCK被认为是可能的递质。一种兴奋性氨基酸受体NMDA受体的激活可引起ttx抗性起搏器样膜电位振荡。5-羟色胺可以通过抑制峰后超极化（Ca2+依赖性钾离子通道）间接发挥增强作用。
The lamprey brainstem and spinal cord can be maintainedin vitro. It is a simple vertebrate preparation with comparatively few neurones. The neural correlates of different patterns of behaviour can be elicited in thisin-vitropreparation. The subject of this review is the neuronal organization underlying locomotion, and, in particular, the role of different types of interneurones and their transmitters and mode of synaptic interaction. Excitatory amino acids, glycine, GABA, 5-HT, tachykinins and CCK have been implied as putative transmitters. The activation of one type of excitatory amino acid receptor, the NMDA receptor, can elicit TTX-resistant pacemaker-like membrane, potential oscillations. 5-HT can exert indirectly a potentiating effect via a depression of the postspike after-hyperpolarization (Ca2+-dependent potassium channels).
影响因子：
56.9
作者：
KANDEL, ER;SCHWARTZ, JH
通讯作者：
SCHWARTZ, JH