Sequence Learning Induces Selectivity to Multiple Task Parameters in Mouse Somatosensory Cortex.
Sequence Learning Induces Selectivity to Multiple Task Parameters in Mouse Somatosensory Cortex.
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DOI：
10.1016/j.cub.2020.10.059
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发表时间：
2021-02-08
期刊：
影响因子：
--
通讯作者：
Maravall M
中科院分区：
文献类型：
--
作者：
Bale MR;Bitzidou M;Giusto E;Kinghorn P;Maravall M
时间顺序和模式是自然信号的关键特征，被大脑用来解码刺激并将其感知为感官对象。为了探索皮层神经元活动如何支持序列辨别，我们开发了一项任务，在该任务中，小鼠区分触觉“单词”序列，该序列由传递到胡须的不同振动构成，以不同的顺序组装。动物舔来报告靶序列的存在。小鼠可以对最早可能的线索做出反应，从而进行区分，有效地解决了“检测变化”的问题，但在稍后做出反应时增强了它们的表现。光遗传失活表明，体感皮层是必要的序列歧视。初级体感“桶”皮层（S1 bf）2/3层的双光子成像显示，在训练有素的动物中，神经元对多个任务变量具有异质选择性，这些变量不仅包括感觉输入，还包括动物的行动决策和试验结果（存在或不存在预测的奖励）。许多神经元在目标导向的舔之前被激活，从而反映了动物对目标序列的反应;这些神经元在小鼠学会将奖励序列与舔相关联时被发现。相比之下，学习引起的感觉反应调谐的变化较小：在幼稚小鼠中发现了对刺激特征作出反应的神经元，并且训练没有产生具有增强的时间整合或分类反应的神经元。因此，在S1 bf中，序列学习导致神经元的活动反映了目标序列和舔之间的学习关联，而不是感官特征的精细表示。小鼠辨别胡须运动序列，区别仅在于它们的元素顺序不同。序列辨别需要通过躯体感觉皮层的感觉输入。桶状皮层神经元反映变量，包括舔的决定和试验结果。当小鼠学习区分目标和非目标有序的胡须运动序列时，分析躯体感觉皮层的第2/3层中的神经元活动。神经元反映任务参数，包括目标序列和舔之间的学习关联，而不是完善其调谐到感官功能。
Sequential temporal ordering and patterning are key features of natural signals, used by the brain to decode stimuli and perceive them as sensory objects. To explore how cortical neuronal activity underpins sequence discrimination, we developed a task in which mice distinguished between tactile “word” sequences constructed from distinct vibrations delivered to the whiskers, assembled in different orders. Animals licked to report the presence of the target sequence. Mice could respond to the earliest possible cues allowing discrimination, effectively solving the task as a “detection of change” problem, but enhanced their performance when responding later. Optogenetic inactivation showed that the somatosensory cortex was necessary for sequence discrimination. Two-photon imaging in layer 2/3 of the primary somatosensory “barrel” cortex (S1bf) revealed that, in well-trained animals, neurons had heterogeneous selectivity to multiple task variables including not just sensory input but also the animal’s action decision and the trial outcome (presence or absence of the predicted reward). Many neurons were activated preceding goal-directed licking, thus reflecting the animal’s learned action in response to the target sequence; these neurons were found as soon as mice learned to associate the rewarded sequence with licking. In contrast, learning evoked smaller changes in sensory response tuning: neurons responding to stimulus features were found in naive mice, and training did not generate neurons with enhanced temporal integration or categorical responses. Therefore, in S1bf, sequence learning results in neurons whose activity reflects the learned association between target sequence and licking rather than a refined representation of sensory features. Mice discriminate whisker motion sequences differing only in their elements’ order Sensory input through somatosensory cortex is needed for sequence discrimination Barrel cortex neurons reflect variables including decision to lick and trial outcome Responses predicting licks appear as soon as mice associate a sequence with licking Bale et al. analyze neuronal activity in layer 2/3 of somatosensory cortex as mice learn to discriminate between a target and a non-target ordered sequence of whisker motion. Neurons reflect task parameters including the learned association between target sequence and licking, rather than refining their tuning to sensory features.
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影响因子：
8.8
作者：
Burgess CP;Lak A;Steinmetz NA;Zatka-Haas P;Bai Reddy C;Jacobs EAK;Linden JF;Paton JJ;Ranson A;Schröder S;Soares S;Wells MJ;Wool LE;Harris KD;Carandini M
通讯作者：
Carandini M
影响因子：
3.5
作者：
Bale MR;Ince RA;Santagata G;Petersen RS
通讯作者：
Petersen RS
DOI：
10.1126/science.1189664
发表时间：
2010-09-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Branco T;Clark BA;Häusser M
通讯作者：
Häusser M
影响因子：
1.9
作者：
Britten, KH;Newsome, WT;Movshon, JA
通讯作者：
Movshon, JA
影响因子：
16.2
作者：
Ceballo, Sebastian;Piwkowska, Zuzanna;Bathellier, Brice
通讯作者：
Bathellier, Brice