The role of pericytes in neurovascular unit remodeling in brain disorders.
The role of pericytes in neurovascular unit remodeling in brain disorders.
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DOI：
10.3390/ijms15046453
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发表时间：
2014-04-16
影响因子：
5.6
通讯作者：
Rivest S
中科院分区：
文献类型：
--
作者：
ElAli A;Thériault P;Rivest S
神经元是非常脆弱的细胞，它们紧密依赖于大脑高度动态和复杂的血管网络，以确保营养和氧气的准确和充分分布。神经血管单元（NVU）将神经元活动与血管功能耦合，控制脑内稳态，并通过基于脑需要调节血脑屏障（BBB）参数来维持足以使神经元存活的最佳脑微环境。NVU是由包括周细胞的不同细胞类型构成的异质结构。周细胞位于脑微血管的近腔侧，并有助于NVU功能。周细胞在胚胎发育期间神经血管系统的发育和成熟以及成年期的稳定性中起重要作用。最初，周细胞被描述为参与控制神经血管张力的收缩细胞。然而，最近的报道表明，周细胞动态响应脑疾病损伤引起的压力，通过化学和物理与邻近细胞的通信，通过它们的免疫特性和它们在神经血管生态位内的潜在多能性。因此，在本文中，我们想回顾周细胞在NVU重塑中的作用，及其作为NVU修复策略靶点的潜力，从而在两种病理生理学不同的脑疾病中发挥神经保护作用：缺血性中风和阿尔茨海默病（AD）。
Neurons are extremely vulnerable cells that tightly rely on the brain’s highly dynamic and complex vascular network that assures an accurate and adequate distribution of nutrients and oxygen. The neurovascular unit (NVU) couples neuronal activity to vascular function, controls brain homeostasis, and maintains an optimal brain microenvironment adequate for neuronal survival by adjusting blood-brain barrier (BBB) parameters based on brain needs. The NVU is a heterogeneous structure constituted by different cell types that includes pericytes. Pericytes are localized at the abluminal side of brain microvessels and contribute to NVU function. Pericytes play essential roles in the development and maturation of the neurovascular system during embryogenesis and stability during adulthood. Initially, pericytes were described as contractile cells involved in controlling neurovascular tone. However, recent reports have shown that pericytes dynamically respond to stress induced by injury upon brain diseases, by chemically and physically communicating with neighboring cells, by their immune properties and by their potential pluripotent nature within the neurovascular niche. As such, in this paper, we would like to review the role of pericytes in NVU remodeling, and their potential as targets for NVU repair strategies and consequently neuroprotection in two pathophysiologically distinct brain disorders: ischemic stroke and Alzheimer’s disease (AD).
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影响因子：
2.9
作者：
Dohgu, S;Takata, F;Kataoka, Y
通讯作者：
Kataoka, Y
骨髓来源的多能细胞是有助于血管化的周细胞
影响因子：
4.8
作者：
Cai, Xiaoxiao;Lin, Yunfeng;Grottkau, Brian E.
通讯作者：
Grottkau, Brian E.
DOI：
10.1073/pnas.0709867105
发表时间：
2008-03-25
影响因子：
11.1
作者：
Arboleda-Velasquez, Joseph F.;Zhou, Zhipeng;Artavanis-Tsakonas, Spyros
通讯作者：
Artavanis-Tsakonas, Spyros
影响因子：
8.3
作者：
Cui X;Chopp M;Zacharek A;Cui Y;Roberts C;Chen J
通讯作者：
Chen J
影响因子：
3.1
作者：
Dore-Duffy, P;Owen, C;Rafols, JA
通讯作者：
Rafols, JA