Increased lung volume in infants and toddlers at high compared to low altitude.
Increased lung volume in infants and toddlers at high compared to low altitude.
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DOI：
10.1002/ppul.22764
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发表时间：
2013-12
影响因子：
3.1
通讯作者：
Tepper, Robert S.
中科院分区：
文献类型：
--
作者：
Llapur, Conrado J.;Martinez, Myriam R.;Marta Caram, Maria;Bonilla, Federico;Cabana, Celia;Yu, Zhansheng;Tepper, Robert S.
关键词：
与低海拔(LA)相比，居住在高海拔(HA)的儿童和成人的肺体积更大；然而，这种对慢性缺氧的反应是否在生命早期就开始尚不清楚。我们的目标是确定HA的婴幼儿是否比LA的婴幼儿有更大的肺体积。测定HA(N=50；3440m)和LA(N=35；440m)婴幼儿血氧饱和度(SaO2)、功能残气量(FRC)及血清血管内皮生长因子(VEGF)和促红细胞生成素(EPO)水平。HA和LA受试者的体型尺寸没有显著差异，但HA受试者的SaO2显著较低(88.5%vs.96.7%；P<；0.0001)。经体长调整后，HA组受试者的FRC显著高于LA组受试者(组平均值分别为209ml和157ml；P<；0.0001)。HA组男性婴儿的FRC显著高于LA组的男性(57毫升；P值=0.001)；然而，HA组女性婴儿的FRC增幅并不显著(20毫升；P值=0.101)。HA受试者的血管内皮生长因子和EPO显著高于LA受试者，没有性别差异。总而言之，HA的婴儿和幼儿与LA的受试者相比，氧饱和度较低，血清VEGF和EPO水平较高，FRC较高；然而，与生命早期的女性婴儿相比，慢性缺氧似乎对男性的肺生长产生了更强劲的反应。
Children and adults residing at high altitude (HA) compared to low altitude (LA) have larger lung volumes; however, it is unknown whether this response to chronic hypoxia begins early in life. Our objective was to determine whether infants and toddlers at HA have larger lung volumes compared to infants and toddlers at LA. Oxygen saturation (SaO2), functional residual capacity (FRC), as well as serum levels of vascular endothelial growth factor (VEGF) and erythropoietin (EPO) were measured in infants and toddlers from HA (N = 50; 3,440 m) and LA (N = 35; 440 m). There were no significant differences in somatic size for HA and LA subjects; however, HA subjects had significantly lower SaO2 (88.5% vs. 96.7%; P < 0.0001). Subjects at HA had significantly greater FRC compared to subjects at LA (group mean: 209 and 157 ml; P < 0.0001), adjusting for body length. Male infants at HA had a significantly greater FRC compared to males at LA (57 ml; P-value < 0.001); however, the increase in FRC for females at HA compared to LA was not significant (20 ml; P-value = 0.101). VEGF and EPO were significantly higher for subjects at HA compared to LA with no gender differences. In summary, infants and toddlers at HA have lower oxygen saturations, higher serum levels of VEGF and EPO, and higher FRC compared to subjects at LA; however, chronic hypoxia appears to generate a more robust response in lung growth in male compared to female infants early in life.
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影响因子：
3.3
作者：
DEGRAFF, AC;GROVER, RF;MILLER, JM
通讯作者：
MILLER, JM
影响因子：
3.1
作者：
JACKSON, EA;RABBETTE, PS;STOCKS, J
通讯作者：
STOCKS, J
影响因子：
2.8
作者：
DROMA, T;MCCULLOUGH, RG;MOORE, LG
通讯作者：
MOORE, LG
DOI：
10.1007/978-0-387-69080-3_42
发表时间：
2008-01-01
期刊：
HORMONAL CARCINOGENESIS V
影响因子：
--
作者：
Applanat, Martine Perrot;Buteau-Lozano, Helene;Corpet, Armelle
通讯作者：
Corpet, Armelle
DOI：
10.1152/ajplung.00228.2004
发表时间：
2004-12-01
影响因子：
4.9
作者：
Massaro, D;Massaro, GD
通讯作者：
Massaro, GD