Increased arterial inflammation in individuals with stage 3 chronic kidney disease.
Increased arterial inflammation in individuals with stage 3 chronic kidney disease.
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第三阶段慢性肾病患者的动脉炎症增加。
DOI：
10.1007/s00259-015-3203-6
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发表时间：
2016
影响因子：
9.1
通讯作者：
Tawakol,Ahmed
中科院分区：
文献类型：
--
作者：
Takx,RichardAP;MacNabb,MeganH;Emami,Hamed;Abdelbaky,Amr;Singh,Parmanand;Lavender,ZacharyR;diCarli,Marcelo;Taqueti,Viviany;Foster,Courtney;Mann,Jessica;Comley,RobertA;Weber,ChekIngKiu;Tawakol,Ahmed
目的：众所周知，慢性肾脏病（CKD）患者发生动脉粥样硬化的风险增加，但尚不清楚轻度CKD患者的动脉炎症是否增加。本研究的目的是比较动脉炎症using 18F-FDG PET/CT在CKD患者和匹配controls.MethodsThis回顾性研究包括128例接受FDG PET/CT成像的临床指征，包括64例患者与第3阶段CKD和64对照组患者的年龄，性别和癌症史相匹配。根据指南使用计算的肾小球滤过率（eGFR）定义CKD。在升主动脉中测量动脉炎症作为PET上的FDG摄取。记录背景FDG摄取（静脉、皮下脂肪和肌肉）。冠状动脉钙化（CAC）的评估使用CT图像。CKD对动脉炎症和CAC的影响，然后assessed.ResultsArterial炎症CKD患者高于匹配的对照组（标准化摄取值，SUV：2.41 ± 0.49与2.16 ± 0.43;P= 0.002）。动脉SUV与eGFR呈负相关（r=-0.299，p = 0.001）。CKD患者的静脉SUV也显著升高，而皮下脂肪和肌肉组织SUV在组间无差异。此外，与对照组相比，在校正肌肉和脂肪背景后，CKD患者的动脉SUV仍然显著升高，并且在校正临床风险因素后仍然显著。此外，CKD与动脉炎症（SUV）的存在下，独立的亚临床动脉粥样硬化（CAC）。此外，动脉炎症的增加与亚临床动脉粥样硬化的存在无关。目前的危险分层工具可能低估了CKD患者动脉粥样硬化的存在，从而低估了心血管事件的风险。
PurposeWhile it is well known that patients with chronic kidney disease (CKD) are at increased risk for the development and progression of atherosclerosis, it is not known whether arterial inflammation is increased in mild CKD. The aim of this study was to compare arterial inflammation using18F-FDG PET/CT in patients with CKD and in matched controls.MethodsThis restrospective study included 128 patients undergoing FDG PET/CT imaging for clinical indications, comprising 64 patients with stage 3 CKD and 64 control patients matched by age, gender, and cancer history. CKD was defined according to guidelines using a calculated glomerular filtration rate (eGFR). Arterial inflammation was measured in the ascending aorta as FDG uptake on PET. Background FDG uptake (venous, subcutaneous fat and muscle) were recorded. Coronary artery calcification (CAC) was assessed using the CT images. The impact of CKD on arterial inflammation and CAC was then assessed.ResultsArterial inflammation was higher in patients with CKD than in matched controls (standardized uptake value, SUV: 2.41 ± 0.49 vs. 2.16 ± 0.43;p= 0.002). Arterial SUV correlated inversely with eGFR (r= −0.299,p= 0.001). Venous SUV was also significantly elevated in patients with CKD, while subcutaneous fat and muscle tissue SUVs did not differ between groups. Moreover, arterial SUV remained significantly elevated in patients with CKD compared to controls after correcting for muscle and fat background, and also remained significant after adjusting for clinical risk factors. Further, CKD was associated with arterial inflammation (SUV) independent of the presence of subclinical atherosclerosis (CAC).ConclusionModerate CKD is associated with increased arterial inflammation beyond that of controls. Further, the increased arterial inflammation is independent of presence of subclinical atherosclerosis. Current risk stratification tools may underestimate the presence of atherosclerosis in patients with CKD and thereby the risk of cardiovascular events.
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影响因子：
20.3
作者：
Ramsay,N;LeBien,T;Nesbit,M;McGlave,P;Weisdorf,D;Kenyon,P;Hurd,D;Goldman,A;Kim,T;Kersey,J
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Kersey,J
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影响因子：
20.3
作者：
Kaizer,H;Stuart,RK;Brookmeyer,R;Beschorner,WE;Braine,HG;Burns,WH;Fuller,DJ;Korbling,M;Mangan,KF;Saral,R
通讯作者：
Saral,R
DOI：
10.1016/s0308-2261(83)80003-4
发表时间：
1983
期刊：
Clinics in haematology
影响因子：
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作者：
Santos,GW
通讯作者：
Santos,GW
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影响因子：
2.7
作者：
C. Buckner;R. Clift;E. Thomas;J. Sanders;R. Hackman;P. Stewart;R. Storb;K. Sullivan
通讯作者：
K. Sullivan
亲脂性染料部花青 540 检测和选择性破坏肿瘤细胞
DOI：
--
发表时间：
1986
期刊：
影响因子：
--
作者：
F. Sieber
通讯作者：
F. Sieber