Detection and Selective Destruction of Tumor Cells by the Lipophilic Dye, Merocyanine 540

Detection and Selective Destruction of Tumor Cells by the Lipophilic Dye, Merocyanine 540
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亲脂性染料部花青 540 检测和选择性破坏肿瘤细胞

DOI:
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发表时间:
1986
期刊:
影响因子:
--
通讯作者:
F. Sieber
F. Sieber
中科院分区:
--
文献类型:
--
作者:
F. Sieber

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大多数细胞与其环境发生一些相互作用,其中已经证明或至少怀疑参与了专门的表面结构。免疫系统细胞对可溶性抗原和细胞抗原的识别、细胞表面受体对生长因子的结合、神经肌肉接头的形成、肿瘤细胞对组织的侵袭、迁移和转移细胞的归巢、胚胎发育过程中模式的形成以及运动和生长的接触抑制都是有指导意义的例子。因此,推测质膜就像指纹一样表征每个细胞的细胞类型、功能活性、年龄、在细胞周期中的位置以及分化和转化的状态是不合理的。而不是由一个定性独特的表面结构(“分化抗原”或“肿瘤抗原”)的特征,假定的指纹可能由几个质膜成分的定量差异的独特组合。
Most cells undergo some interactions with their environment where the involvement of specialized surface structures has been demonstrated or is at least suspected. The recognition of soluble and cellular antigens by cells of the immune system, the binding of growth factors by cell surface receptors, the formation of neuromuscular junctions, the invasion of tissues by tumor cells, the homing of migrating and metastasizing cells, the formation of patterns during embryonic development, and contact inhibition of movement and growth are instructive examples. It is, therefore, not unreasonable to speculate that the plasma membrane characterizes like a fingerprint each cell with regard to cell type, functional activity, age, position in the cell cycle, and state of differentiation and transformation. Rather than being characterized by one qualitatively unique surface structure (“differentiation antigen” or “tumor antigen”) the postulated fingerprints may consist of unique combinations of quantitative differences in several plasma membrane components.
早期鹌鹑神经嵴细胞之间的异质性。
DOI: 10.1016/0165-3806(84)90308-0
发表时间: 1984
期刊: Brain research
影响因子: 2.9
作者:
Sieber-Blum,M;Sieber,F
通讯作者: Sieber,F
部花青 540 可识别慢性粒细胞白血病中的红细胞膜异常。
DOI: 10.1016/0309-1651(85)90140-7
发表时间: 1985
期刊: Cell biology international reports
影响因子: --
作者:
Reed,JA;Kough,RH;Williamson,PL;Schlegel,RA
通讯作者: Schlegel,RA
小鼠造血干细胞对部花青540的敏感性差异。
DOI: 10.1111/j.1432-0436.1981.tb01129.x
发表时间: 1981
期刊: Differentiation; research in biological diversity
影响因子: --
作者:
Sieber,F;Meagher,RC;Spivak,JL
通讯作者: Spivak,JL
染料介导的小鼠神经母细胞瘤细胞的光敏化。
DOI: --
发表时间: 1986
期刊: Cancer research
影响因子: 11.2
作者:
Sieber,F;Sieber-Blum,M
通讯作者: Sieber-Blum,M
通过部花青 540 介导的光敏作用选择性杀死白血病细胞。
DOI: 10.1073/pnas.81.23.7584
发表时间: 1984
影响因子: 11.1
作者:
Sieber,F;Spivak,JL;Sutcliffe,AM
通讯作者: Sutcliffe,AM