Brush-On Fabrication of Suspended PLLA-PEO-PLLA Triblock Copolymer Fibers
Brush-On Fabrication of Suspended PLLA-PEO-PLLA Triblock Copolymer Fibers
复制标题
悬浮 PLLA-PEO-PLLA 三嵌段共聚物纤维的刷涂制备
DOI：
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
R. Keynton
中科院分区：
文献类型：
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作者：
S. Berry;S. Pabba;J. Fernandes;Jeremy M. Rathfon;Khaled A. Aamer;G. Tew;A. Gobin;R. Cohn;R. Keynton
通过在微制造的柱阵列上手动刷涂溶剂化聚合物溶液，可以快速创建平行纤维。最近，该技术已被用来生产微米和亚微米级纤维的悬浮阵列，该纤维由一种新型三嵌段共聚物组成，该三嵌段共聚物由聚环氧乙烷（PEO）的亲水性中间嵌段和两个聚-L-乳酸（PLLA）疏水性端基包围组成。这种聚合物的氯仿溶液已用于制造直径范围为 125 nm 至 >50 μm 的纤维。在水中对这些纤维进行退火会导致超微结构纳米级孔的形成，这些孔可以通过表面处理的变化选择性地定向。由于 PLLA-PEO-PLLA 三嵌段共聚物既具有生物相容性又可生物降解，因此这些纤维阵列是仿生细胞外基质 (ECM) 结构的绝佳候选者。此外，纤维的多孔超微结构可以为生长因子的原位递送提供平台，以刺激内皮细胞增殖、迁移和管腔形成。
Parallel fibers can be rapidly created by manually brushing solvated polymer solutions over arrays of microfabricated pillars. Recently, this technique has been utilized to produce suspended arrays of micron and sub-micron scale fibers consisting of a new triblock copolymer composed of a hydrophilic mid-block of polyethylene oxide (PEO) surrounded by two hydrophobic end groups of poly-L-lactic acid (PLLA). A solution of this polymer in chloroform has been used to fabricate fibers with diameters ranging from 125 nm to >50 μm. Annealing these fibers in water induces the formation of ultrastructural nanoscale pores that can be selectively oriented through variation of the surface treatment. Because the PLLA-PEO-PLLA triblock copolymer is both biocompatible and biodegradable, these arrays of fibers are excellent candidates for biomimetic extracellular matrix (ECM) structures. Additionally, the porous ultrastructure of the fibers may provide a platform for the in situ delivery of growth factors to stimulate endothelial cell proliferation, migration, and lumen formation.
影响因子：
14
作者：
Kane, RS;Takayama, S;Whitesides, GM
通讯作者：
Whitesides, GM
影响因子：
10.8
作者：
Agrawal, SK;Sanabria-DeLong, N;Bhatia, SR
通讯作者：
Bhatia, SR