Intracellular calcium movements during excitation-contraction coupling in mammalian slow-twitch and fast-twitch muscle fibers.

Intracellular calcium movements during excitation-contraction coupling in mammalian slow-twitch and fast-twitch muscle fibers.
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DOI:
10.1085/jgp.201210773
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发表时间:
2012-04
期刊:
The Journal of general physiology
影响因子:
--
通讯作者:
Hollingworth S
Hollingworth S
中科院分区:
其他
文献类型:
--
作者:
Baylor SM;Hollingworth S

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在骨骼肌纤维中,动作电位通过从肌浆网释放钙离子(Ca2+)引起收缩。对单个小鼠肌肉纤维微注射快速反应的荧光Ca2+指示染料的实验表明,Ca2+释放量在快肌纤维中比在慢肌纤维中大三到四倍,并且释放的Ca2+结合肌钙蛋白激活收缩的比例要小得多。
In skeletal muscle fibers, action potentials elicit contractions by releasing calcium ions (Ca2+) from the sarcoplasmic reticulum. Experiments on individual mouse muscle fibers micro-injected with a rapidly responding fluorescent Ca2+ indicator dye reveal that the amount of Ca2+ released is three- to fourfold larger in fast-twitch fibers than in slow-twitch fibers, and the proportion of the released Ca2+ that binds to troponin to activate contraction is substantially smaller.
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