The key role of sphingolipid metabolism in cancer: New therapeutic targets, diagnostic and prognostic values, and anti-tumor immunotherapy resistance.
The key role of sphingolipid metabolism in cancer: New therapeutic targets, diagnostic and prognostic values, and anti-tumor immunotherapy resistance.
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DOI：
10.3389/fonc.2022.941643
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发表时间：
2022
影响因子：
4.7
通讯作者：
Leung, Elaine Lai-Han
中科院分区：
文献类型：
--
作者：
Li, Run-Ze;Wang, Xuan-Run;Wang, Jian;Xie, Chun;Wang, Xing-Xia;Pan, Hu-Dan;Meng, Wei-Yu;Liang, Tu-Liang;Li, Jia-Xin;Yan, Pei-Yu;Wu, Qi-Biao;Liu, Liang;Yao, Xiao-Jun;Leung, Elaine Lai-Han
具有生物活性的鞘脂与癌细胞的生长、分化、衰老和凋亡密切相关。神经酰胺等鞘脂是鞘脂代谢途径中的有利代谢物，通常通过抑制癌细胞生长和迁移，诱导自噬和凋亡来介导抗增殖反应。而其他鞘脂，如S1P，则发挥相反的作用，诱导癌细胞转化、迁移和生长，促进耐药。还有其他鞘脂，以及酶，在癌症生理学和治疗中发挥着潜在的关键作用。本文旨在探讨鞘脂代谢在肿瘤中的重要作用。本文就鞘脂代谢在肿瘤中的作用和价值进行综述，包括鞘脂的分布、功能及其与肿瘤诊断和预后的关系。综述了鞘脂代谢中已知的和潜在的抗肿瘤靶点，分析了鞘脂代谢与肿瘤免疫的相关性，总结了基于鞘脂的天然化合物的抗肿瘤作用。通过对鞘脂类抗肿瘤治疗靶点及免疫相关性的分析和总结，旨在为开发新的抗肿瘤药物、探索新的肿瘤治疗手段、研究免疫治疗耐药机制提供思路。
Biologically active sphingolipids are closely related to the growth, differentiation, aging, and apoptosis of cancer cells. Some sphingolipids, such as ceramides, are favorable metabolites in the sphingolipid metabolic pathway, usually mediating antiproliferative responses, through inhibiting cancer cell growth and migration, as well as inducing autophagy and apoptosis. However, other sphingolipids, such as S1P, play the opposite role, which induces cancer cell transformation, migration and growth and promotes drug resistance. There are also other sphingolipids, as well as enzymes, played potentially critical roles in cancer physiology and therapeutics. This review aimed to explore the important roles of sphingolipid metabolism in cancer. In this article, we summarized the role and value of sphingolipid metabolism in cancer, including the distribution of sphingolipids, the functions, and their relevance to cancer diagnosis and prognosis. We also summarized the known and potential antitumor targets present in sphingolipid metabolism, analyzed the correlation between sphingolipid metabolism and tumor immunity, and summarize the antitumor effects of natural compounds based on sphingolipids. Through the analysis and summary of sphingolipid antitumor therapeutic targets and immune correlation, we aim to provide ideas for the development of new antitumor drugs, exploration of new therapeutic means for tumors, and study of immunotherapy resistance mechanisms.
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影响因子：
5.2
作者：
Gupta P;Taiyab A;Hussain A;Alajmi MF;Islam A;Hassan MI
通讯作者：
Hassan MI
影响因子：
3.5
作者：
Bai, Aiping;Szulc, Zdzislaw M.;Bielawska, Alicja
通讯作者：
Bielawska, Alicja
DOI：
10.1073/pnas.1115484108
发表时间：
2011-12-06
影响因子：
11.1
作者：
Barcelo-Coblijn, Gwendolyn;Laura Martin, Maria;Escriba, Pablo V.
通讯作者：
Escriba, Pablo V.
DOI：
10.1006/bbrc.2001.5045
发表时间：
2001-06-22
影响因子：
3.1
作者：
Grassmé, H;Schwarz, H;Gulbins, E
通讯作者：
Gulbins, E
影响因子：
5.2
作者：
El-Hindi, Khadija;Brachtendorf, Sebastian;Groesch, Sabine
通讯作者：
Groesch, Sabine