Bacteriophages and their genomes.
Bacteriophages and their genomes.
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DOI：
10.1016/j.coviro.2011.06.009
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发表时间：
2011-10
影响因子：
5.9
通讯作者：
Hendrix, Roger W.
中科院分区：
文献类型：
--
作者：
Hatfull, Graham F.;Hendrix, Roger W.
噬菌体在生物学中占有独特的地位，代表了生物圈中所有生物体的绝对多数。由于它们的基因组相对较小，阐明噬菌体种群的遗传多样性，破译它们的起源，并确定塑造种群的进化机制似乎是可行的。然而，噬菌体基因组表征的步伐在过去三年中有所放缓，这在一定程度上反映出需要从对已知和特征充分的噬菌体进行测序过渡到对新分离物的分离和比较分析。噬菌体基因组学的现状表明，噬菌体种群的遗传多样性非常高，噬菌体在水平遗传交换的积极参与下已经进化了数十亿年，因此它们的基因组在它们的结构中普遍镶嵌。但我们仅仅触及了表面，未来几年的噬菌体基因组探索有望带来特别的启示。
Bacteriophages occupy a unique position in biology, representing an absolute majority of all organisms in the biosphere. Because their genomes are relatively small, elucidating the genetic diversity of the phage population, deciphering their origins, and identifying the evolutionary mechanisms that shape the population would seem readily feasible. And yet the pace of phage genome characterization has slowed over the past three years, reflecting in part a need to transition from sequencing known and well-characterized bacteriophages to the isolation and comparative analysis of new isolates. The current state of bacteriophage genomics shows that the genetic diversity of the population is very high, that phages have been actively evolving for billions of years with active engagement of horizontal genetic exchange, and that their genomes are consequently pervasively mosaic in their architectures. But we have barely scratched the surface and the next years of phage genome exploration promise to be especially revealing.
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DOI：
10.1073/pnas.0808832106
发表时间：
2009-01-20
影响因子：
11.1
作者：
Fineran, Peter C.;Blower, Tim R.;Salmond, George P. C.
通讯作者：
Salmond, George P. C.
影响因子：
14.9
作者：
McMahon SA;Roberts GA;Johnson KA;Cooper LP;Liu H;White JH;Carter LG;Sanghvi B;Oke M;Walkinshaw MD;Blakely GW;Naismith JH;Dryden DT
通讯作者：
Dryden DT
影响因子：
4.5
作者：
Martinsohn JT;Radman M;Petit MA
通讯作者：
Petit MA
影响因子：
3.2
作者：
Kwan, T;Liu, J;Pelletier, J
通讯作者：
Pelletier, J
影响因子：
11.4
作者：
AMITSUR, M;LEVITZ, R;KAUFMANN, G
通讯作者：
KAUFMANN, G