Rapid and stable mobilization of CD8(+) T cells by SARS-CoV-2 mRNA vaccine.
Rapid and stable mobilization of CD8(+) T cells by SARS-CoV-2 mRNA vaccine.
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DOI：
10.1038/s41586-021-03841-4
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发表时间：
2021-09
期刊：
影响因子：
64.8
通讯作者：
Hofmann M
中科院分区：
文献类型：
--
作者：
Oberhardt V;Luxenburger H;Kemming J;Schulien I;Ciminski K;Giese S;Csernalabics B;Lang-Meli J;Janowska I;Staniek J;Wild K;Basho K;Marinescu MS;Fuchs J;Topfstedt F;Janda A;Sogukpinar O;Hilger H;Stete K;Emmerich F;Bengsch B;Waller CF;Rieg S;Sagar;Boettler T;Zoldan K;Kochs G;Schwemmle M;Rizzi M;Thimme R;Neumann-Haefelin C;Hofmann M
SARS-CoV-2刺突mRNA疫苗最早在初次接种后10天介导对严重疾病的保护，此时几乎检测不到中和抗体。因此，疫苗诱导的CD 8 + T细胞可能是早期阶段保护作用的主要介质。然而，其诱导的细节、与自然感染的比较以及与疫苗诱导的免疫的其他分支的关联仍然不完全清楚。在这里，我们在单表位水平上显示，当循环中的CD 4 + T细胞和中和抗体仍然微弱可检测时，在用bnt 162 b2初次接种后一周，稳定且功能齐全的CD 8 + T细胞应答被有力地动员。加强疫苗接种诱导产生高度分化的效应CD 8 + T细胞的稳健扩增;然而，功能能力和记忆前体T细胞库均不受影响。与自然感染相比，疫苗诱导的早期记忆T细胞表现出相似的功能能力，但不同的亚群分布。我们的研究结果表明，CD 8 + T细胞是重要的效应细胞，在初免疫苗接种后的早期保护窗口中扩增，先于疫苗诱导免疫的其他效应臂成熟，并在加强疫苗接种后稳定维持。对SARS-CoV-2 mRNA疫苗诱导的表位特异性CD 8 + T细胞应答的纵向分析表明，CD 8 + T细胞在初免疫苗接种后迅速诱导，并在加强疫苗接种后稳定维持。
SARS-CoV-2 spike mRNA vaccines mediate protection from severe disease as early as ten days after prime vaccination, when neutralizing antibodies are hardly detectable. Vaccine-induced CD8+ T cells may therefore be the main mediators of protection at this early stage. The details of their induction, comparison to natural infection, and association with other arms of vaccine-induced immunity remain, however, incompletely understood. Here we show on a single-epitope level that a stable and fully functional CD8+ T cell response is vigorously mobilized one week after prime vaccination with bnt162b2, when circulating CD4+ T cells and neutralizing antibodies are still weakly detectable. Boost vaccination induced a robust expansion that generated highly differentiated effector CD8+ T cells; however, neither the functional capacity nor the memory precursor T cell pool was affected. Compared with natural infection, vaccine-induced early memory T cells exhibited similar functional capacities but a different subset distribution. Our results indicate that CD8+ T cells are important effector cells, are expanded in the early protection window after prime vaccination, precede maturation of other effector arms of vaccine-induced immunity and are stably maintained after boost vaccination. Longitudinal analyses of SARS-CoV-2 mRNA vaccine-elicited epitope-specific CD8+ T cell responses shows that CD8+ T cells are rapidly induced after prime vaccination and stably maintained after boost vaccination.
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BNT162B2 mRNA COVID-19疫苗的安全性和功效。
DOI：
10.1056/nejmoa2034577
发表时间：
2020-12-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Polack FP;Thomas SJ;Kitchin N;Absalon J;Gurtman A;Lockhart S;Perez JL;Pérez Marc G;Moreira ED;Zerbini C;Bailey R;Swanson KA;Roychoudhury S;Koury K;Li P;Kalina WV;Cooper D;Frenck RW Jr;Hammitt LL;Türeci Ö;Nell H;Schaefer A;Ünal S;Tresnan DB;Mather S;Dormitzer PR;Şahin U;Jansen KU;Gruber WC;C4591001 Clinical Trial Group
通讯作者：
C4591001 Clinical Trial Group
SARS-COV-2 mRNA疫苗促进与中和抗体产生相关的有效抗原特异性生发中心反应。
影响因子：
32.4
作者：
Lederer K;Castaño D;Gómez Atria D;Oguin TH 3rd;Wang S;Manzoni TB;Muramatsu H;Hogan MJ;Amanat F;Cherubin P;Lundgreen KA;Tam YK;Fan SHY;Eisenlohr LC;Maillard I;Weissman D;Bates P;Krammer F;Sempowski GD;Pardi N;Locci M
通讯作者：
Locci M
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
影响因子：
24.8
作者：
Goel RR;Apostolidis SA;Painter MM;Mathew D;Pattekar A;Kuthuru O;Gouma S;Hicks P;Meng W;Rosenfeld AM;Dysinger S;Lundgreen KA;Kuri-Cervantes L;Adamski S;Hicks A;Korte S;Oldridge DA;Baxter AE;Giles JR;Weirick ME;McAllister CM;Dougherty J;Long S;D'Andrea K;Hamilton JT;Betts MR;Luning Prak ET;Bates P;Hensley SE;Greenplate AR;Wherry EJ
通讯作者：
Wherry EJ
影响因子：
30.5
作者：
Kaech, SM;Ahmed, R
通讯作者：
Ahmed, R