Neurocognitive endophenotypes for bipolar disorder identified in multiplex multigenerational families.
Neurocognitive endophenotypes for bipolar disorder identified in multiplex multigenerational families.
复制标题
DOI：
10.1001/archgenpsychiatry.2009.184
复制
发表时间：
2010-02
影响因子：
--
通讯作者：
Escamilla, Michael A.
中科院分区：
文献类型：
--
作者：
Glahn, David C.;Almasy, Laura;Barguil, Marcela;Hare, Elizabeth;Peralta, Juan Manuel;Kent, Jack W., Jr.;Dassori, Albana;Contreras, Javier;Pacheco, Adriana;Lanzagorta, Nuria;Nicolini, Humberto;Raventos, Henriette;Escamilla, Michael A.
虽然遗传因素对双相情感障碍的影响已经得到了很好的证实，但对易患该疾病的基因进行定位已被证明是困难的。考虑到诱发双相情感障碍的基因可能在没有分类临床表型表达的情况下传播，识别风险基因的一种策略是使用定量内表型。本研究的目的是判定双相情感障碍的神经认知内表型。来自哥斯达黎加、墨西哥城或德克萨斯州圣安东尼奥的中央谷的709名拉丁美洲人参加了这项研究。这些人中有660人是至少有两个兄弟姐妹被诊断为双相情感障碍的扩展家系成员（n=230）。其余受试者为社区对照，来自每个研究中心，没有双相情感障碍或精神分裂症的个人或家族史。所有受试者接受心理诊断访谈和全面的神经认知评估。被发现具有遗传性的神经认知指标被纳入分析，以确定哪些测试在受影响的个体中受损，对疾病的遗传易感性敏感，并与情感状态遗传相关。主要结果测量是神经认知测试表现。21个神经认知变量中有两个没有显著的遗传性，并从随后的分析中排除。与非相关的健康受试者相比，双相情感障碍患者在这些认知测量中的6项上受损。非双相一级亲属在其中五项测试中受损，三项测试与情感状态遗传相关：数字符号编码，对象延迟反应和即时面部记忆。这项关于双相情感障碍认知功能的大规模扩展谱系研究确定了处理速度、工作记忆和陈述性（面部）记忆的测量值作为双相情感障碍的候选内表型。
Although genetic influences on bipolar disorder are well established, localization of genes that predispose to the illness has proven difficult. Given that genes predisposing to bipolar disorder may be transmitted without expression of the categorical clinical phenotype, one strategy for identifying risk genes is the use of quantitative endophenotypes. The goal of the current study is to adjudicate neurocognitive endophenotypes for bipolar disorder. 709 Latino individuals from the central valley of Costa Rica, Mexico City, Mexico, or San Antonio, Texas participated in the study. 660 of these persons were members of extended pedigrees with at least two siblings diagnosed with bipolar disorder (n=230). The remaining subjects were community controls drawn from each site and without personal or family history of bipolar disorder or schizophrenia. All subjects received psychodiagnostic interviews and comprehensive neurocognitive evaluations. Neurocognitive measures found to be heritable were entered into analyses designed to determine which tests are impaired in affected individuals, sensitive to genetic liability for the illness and genetically correlated with affection status. The main outcome measure was neurocognitive test performance. Two of the 21 neurocognitive variables were not significantly heritable and were excluded from subsequent analyses. Patients with bipolar disorder were impaired on 6 of these cognitive measures compared to non-related healthy subjects. Non-bipolar first-degree relatives were impaired on five of these and three tests were genetically correlated with affection status: digit symbol coding, object delayed response, and immediate facial memory. This large-scale extended pedigree study of cognitive functioning in bipolar disorder identified measures of processing speed, working memory and declarative (facial) memory as candidate endophenotypes for bipolar disorder.
登录
查看更多内容
影响因子：
6.9
作者：
Glahn, David C.;Barrett, Jennifer;Velligan, Dawn I.
通讯作者：
Velligan, Dawn I.
影响因子：
30.8
作者：
Ferreira, Manuel A. R.;O'Donovan, Michael C.;Meng, Yan A.;Jones, Ian R.;Ruderfer, Douglas M.;Jones, Lisa;Fan, Jinbo;Kirov, George;Perlis, Roy H.;Green, Elaine K.;Smoller, Jordan W.;Grozeva, Detelina;Stone, Jennifer;Nikolov, Ivan;Chambert, Kimberly;Hamshere, Marian L.;Nimgaonkar, Vishwajit L.;Moskvina, Valentina;Thase, Michael E.;Caesar, Sian;Sachs, Gary S.;Franklin, Jennifer;Gordon-Smith, Katherine;Ardlie, Kristin G.;Gabriel, Stacey B.;Fraser, Christine;Blumenstiel, Brendan;Defelice, Matthew;Breen, Gerome;Gill, Michael;Morris, Derek W.;Elkin, Amanda;Muir, Walter J.;McGhee, Kevin A.;Williamson, Richard;MacIntyre, Donald J.;MacLean, Alan W.;Clair, David St;Robinson, Michelle;Van Beck, Margaret;Pereira, Ana C. P.;Kandaswamy, Radhika;McQuillin, Andrew;Collier, David A.;Bass, Nicholas J.;Young, Allan H.;Lawrence, Jacob;Ferrier, I. Nicol;Anjorin, Adebayo;Farmer, Anne;Curtis, David;Scolnick, Edward M.;McGuffin, Peter;Daly, Mark J.;Corvin, Aiden P.;Holmans, Peter A.;Blackwood, Douglas H.;Gurling, Hugh M.;Owen, Michael J.;Purcell, Shaun M.;Sklar, Pamela;Craddock, Nick
通讯作者：
Craddock, Nick
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
6.6
作者：
Craddock, N;O'Donovan, MC;Owen, MJ
通讯作者：
Owen, MJ
影响因子：
10.4
作者：
Blangero, J;Williams, JT;Almasy, L
通讯作者：
Almasy, L