Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals.
Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals.
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通过基因切除IκB激酶（IKK）介导的B细胞系中NF-κB活化，并通过分析小鼠突变体（其中IGλ+ B细胞在Igk重排缺失的情况下产生），我们定义了早期B细胞发育的两个不同的连续阶段，其对IKK介导的NF-κB信号的依赖性不同。在第一阶段，NF-κB信号传导被阻断，主要产生IGκ+ B细胞并进行有效的受体编辑。在第二阶段，主要产生IGλ+ B细胞，其发育在个体发生学上定时在Igk重排之后发生。发育的第二阶段依赖于NF-κB信号，其可被促存活因子Bcl 2的转基因表达所取代。
By genetically ablating IκB kinase (IKK)-mediated NF-κB activation in the B cell lineage, and by analyzing a mouse mutant in which Igλ+ B cells are generated in the absence of rearrangements in Igk, we define two distinct, consecutive phases of early B cell development that differ in their dependence on IKK-mediated NF-κB signaling. During the first phase, in which NF-κB signaling is dispensable, predominantly Igκ+ B cells are generated and undergo efficient receptor editing. In the second phase, predominantly Igλ+ B cells are generated, whose development is ontogenetically timed to occur after Igk rearrangements. This second phase of development is dependent on NF-κB signals, which can be substituted by transgenic expression of the pro-survival factor Bcl2.
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DOI：
10.1084/jem.185.4.609
发表时间：
1997-02-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Constantinescu A;Schlissel MS
通讯作者：
Schlissel MS
影响因子：
32.4
作者：
Kawai, T;Adachi, O;Akira, S
通讯作者：
Akira, S
DOI：
10.1084/jem.20042020
发表时间：
2005-01-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1084/jem.186.9.1513
发表时间：
1997-11-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Lang J;Arnold B;Hammerling G;Harris AW;Korsmeyer S;Russell D;Strasser A;Nemazee D
通讯作者：
Nemazee D
影响因子：
20.3
作者：
Lindsley, Robert Coleman;Thomas, Matthew;Allman, David
通讯作者：
Allman, David