Association between "solute carrier family 30 member 8" (SLC30A8) gene polymorphism and susceptibility to type 2 diabetes mellitus in Chinese Han and minority populations: an updated meta-analysis.
Association between "solute carrier family 30 member 8" (SLC30A8) gene polymorphism and susceptibility to type 2 diabetes mellitus in Chinese Han and minority populations: an updated meta-analysis.
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中国汉族和少数民族人群“溶质载体家族30成员8”（SLC30A8）基因多态性与2型糖尿病易感性之间的关联：更新的荟萃分析。
DOI：
10.6133/apjcn.201811_27(6).0025
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发表时间：
2018
影响因子：
1.3
通讯作者：
Li Wenjie
中科院分区：
文献类型：
--
作者：
Wang Yan;Duan Leizhen;Yu Songcheng;Liu Xinxin;Han Han;Wang Jun;Li Wenjie
背景与目的 在中国，已有一些研究报道溶质载体家族30成员8（SLC30A8）基因多态性可能会增加2型糖尿病（T2DM）的风险，但也有一些研究结果并非如此。本荟萃分析的目的是系统地研究……
BACKGROUND AND OBJECTIVES
In China, some studies have been reported that solute carrier family 30 member 8 (SLC30A8) gene polymorphism might increase the risk of T2DM, but some are not. The aim of this meta-analysis was to systematically investigate the association between the rs13266634 polymorphism of the SLC30A8 gene and T2DM in Chinese Han and ethnic minority populations.
METHODS AND STUDY DESIGN
All published electronic articles were retrieved from Pubmed, Web of Knowledge, Chinese National Knowledge Infrastructure (CNKI), Wanfang database, VIP database and Google scholar. Pooled OR and 95% CI were calculated using random- or fixed-effects models.
RESULTS
Twenty-five articles involving 62,285 subjects were included in this metaanalysis. Considering the total population, significant associations between the rs13266634 polymorphism and T2DM were observed under the allele model (C vs T: OR=1.23, 95% CI=1.18-1.29), the additive models ( CC vs TT: OR=1.44, 95% CI=1.32-1.56; CC vs CT: OR=1.08, 95% CI=1.02-1.15; CT vs TT: OR=1.25, 95% CI=1.15- 1.37), the dominant model (CC vs CT+TT: OR=1.24, 95% CI=1.17-1.32) and the recessive model (CC+CT vs TT: OR=1.26, 95% CI=1.16-1.35). Based on subgroup analysis, besides the CC vs CT model, these associations were stronger in the ethnic minority groups than in the Han population. Moreover, no association was observed under the CC vs CT model (OR=1.26, 95% CI=0.95-1.66, p=0.105) in ethnic minority groups.
CONCLUSIONS
Chinese C allele carriers could have an increased risk of T2DM. Well-designed future studies should be conducted with a larger sample size to better understand this association in ethnic minority groups.
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