Gold nanoparticle-based brachytherapy enhancement in choroidal melanoma using a full Monte Carlo model of the human eye.
Gold nanoparticle-based brachytherapy enhancement in choroidal melanoma using a full Monte Carlo model of the human eye.
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DOI：
10.1120/jacmp.v16i5.5568
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发表时间：
2015-09-08
影响因子：
2.1
通讯作者：
Meigooni AS
中科院分区：
文献类型：
--
作者：
Asadi S;Vaez-zadeh M;Masoudi SF;Rahmani F;Knaup C;Meigooni AS
采用蒙特卡罗模拟技术研究了金纳米粒子（GNP）在脉络膜黑色素瘤125I近距离治疗剂量增强中的作用。通常，蒙特卡罗眼科近距离放射治疗剂量测定是在水模体中进行的。然而，在这里，已经考虑了人眼的成分而不是水。用MCNP 5程序模拟了人眼和水的幻象。这些模拟是针对含有13个125I粒子的满载16 mm COMS眼斑进行的。已经在具有和不具有GNP的体模中计算了递送至肿瘤和正常组织的剂量。通常，癌症患者的放射治疗旨在向肿瘤提供所需剂量，同时保留周围的正常组织。然而，由于正常细胞和癌细胞以几乎相同的方式吸收剂量，因此正常组织在治疗期间吸收辐射剂量。GNP与放射疗法组合用于治疗肿瘤降低了正常组织的吸收剂量。结果表明，植入COMS斑块的眼球中肿瘤的剂量随着靶内GNP浓度的增加而增加。因此，通过在治疗前加入GNP，减少了眼睛中肿瘤所需的照射时间。结果，当照射时间减少时，对正常组织的剂量减少。此外，在GNP存在下，由水制成的眼模型和由人眼组成的眼模型中的模拟数据之间的比较显示了在眼科近距离放射治疗剂量测定中利用眼睛的组成的意义。此外，定义眼睛组成而不是水导致更准确地计算GNP在眼科近距离放射治疗剂量测定中的辐射效应。PACS编号：87.53.Jw、87.85.Rs、87.10.Rt
The effects of gold nanoparticles (GNPs) in 125I brachytherapy dose enhancement on choroidal melanoma are examined using the Monte Carlo simulation technique. Usually, Monte Carlo ophthalmic brachytherapy dosimetry is performed in a water phantom. However, here, the compositions of human eye have been considered instead of water. Both human eye and water phantoms have been simulated with MCNP5 code. These simulations were performed for a fully loaded 16 mm COMS eye plaque containing 13 125I seeds. The dose delivered to the tumor and normal tissues have been calculated in both phantoms with and without GNPs. Normally, the radiation therapy of cancer patients is designed to deliver a required dose to the tumor while sparing the surrounding normal tissues. However, as the normal and cancerous cells absorbed dose in an almost identical fashion, the normal tissue absorbed radiation dose during the treatment time. The use of GNPs in combination with radiotherapy in the treatment of tumor decreases the absorbed dose by normal tissues. The results indicate that the dose to the tumor in an eyeball implanted with COMS plaque increases with increasing GNPs concentration inside the target. Therefore, the required irradiation time for the tumors in the eye is decreased by adding the GNPs prior to treatment. As a result, the dose to normal tissues decreases when the irradiation time is reduced. Furthermore, a comparison between the simulated data in an eye phantom made of water and eye phantom made of human eye composition, in the presence of GNPs, shows the significance of utilizing the composition of eye in ophthalmic brachytherapy dosimetry Also, defining the eye composition instead of water leads to more accurate calculations of GNPs radiation effects in ophthalmic brachytherapy dosimetry. PACS number: 87.53.Jw, 87.85.Rs, 87.10.Rt
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影响因子：
3.5
作者：
Cho, SH
通讯作者：
Cho, SH
影响因子：
0.6
作者：
Cho, Sungkoo;Jeong, Jong Hwi;Yoon, Myonggeun
通讯作者：
Yoon, Myonggeun
影响因子：
3.1
作者：
Brualla, L.;Sempau, J.;Sauerwein, W.
通讯作者：
Sauerwein, W.
影响因子：
3.8
作者：
Chiu-Tsao, Sou-Tung;Astrahan, Melvin A.;Thomson, Rowan M.
通讯作者：
Thomson, Rowan M.
影响因子：
1.6
作者：
Fuss, M. C.;Munoz, A.;Garcia, G.
通讯作者：
Garcia, G.