Round window closure affects cochlear responses to suprathreshold stimuli.
Round window closure affects cochlear responses to suprathreshold stimuli.
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DOI：
10.1002/lary.24394
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发表时间：
2013-12
期刊：
影响因子：
2.6
通讯作者：
Hu, Bo Hua
中科院分区：
文献类型：
--
作者：
Cai, Qunfeng;Whitcomb, Carolyn;Eggleston, Jessica;Sun, Wei;Salvi, Richard;Hu, Bo Hua
圆窗作为释放内耳压力和促进基底膜振动的通风口。这种通气功能的丧失会影响耳蜗功能，导致听力障碍。本研究旨在研究圆窗闭合后耳蜗对阈上刺激的反应，以确定可能用于圆窗闭锁临床诊断的功能变化。前瞻性对照动物研究。建立大鼠圆窗阻塞模型。利用该模型，对听性脑干反应阈值、畸变产物耳声发射和声惊吓反应的输入/输出函数进行了研究。圆窗关闭引起听性脑干反应阈值轻度偏移（13.5 ± 9.1 dB）。它还降低了失真产物耳声发射的幅度和输入/输出函数的斜率。这种外周变化伴随着声惊吓反射（一种对阈上声音的运动反应）的振幅显著降低，但阈值未降低。除了引起轻度增加的听觉脑干反应的阈值，圆窗闭塞降低的斜率失真产品耳声发射和惊吓反射输入/输出功能。这些变化不同于典型的传导性或感觉性听力损失，可能存在于圆窗闭锁患者中。然而，需要对患者进行进一步的临床观察来证实这些发现。
The round window acts as a vent for releasing inner ear pressure and facilitating basilar membrane vibration. Loss of this venting function affects cochlear function leading to hearing impairment. The current investigation was designed to examine how the cochlea responds to supra-threshold stimuli following round window closure in an effort to identify functional changes that might be used in clinical diagnosis of round window atresia. Prospective, controlled, animal study. A rat model of round window occlusion was established. With this model, the thresholds of auditory brainstem responses and the input/output functions of distortion product otoacoustic emissions and acoustic startle responses were examined. Round window closure caused a mild shift in the thresholds of the auditory brainstem response (13.5 ± 9.1 dB). It also reduced the amplitudes of the distortion product otoacoustic emissions and the slope of the input/output functions. This peripheral change was accompanied by a significant reduction in the amplitude, but not the threshold, of the acoustic startle reflex, a motor response to supra-threshold sounds. In addition to causing mild increase in the threshold of the auditory brainstem response, round window occlusion reduced the slopes of both distortion product otoacoustic emissions and startle reflex input/output functions. These changes differ from those observed for typical conductive or sensory hearing loss, and could be present in patients with round window atresia. However, future clinical observations in patients are needed to confirm these findings.
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