Salicylate increases the gain of the central auditory system.
Salicylate increases the gain of the central auditory system.
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DOI：
10.1016/j.neuroscience.2008.12.024
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发表时间：
2009-03-03
期刊：
影响因子：
3.3
通讯作者：
Salvi, R. J.
中科院分区：
文献类型：
--
作者：
Sun, W.;Lu, J.;Stolzberg, D.;Gray, L.;Deng, A.;Lobarinas, E.;Salvi, R. J.
高剂量的水杨酸盐，阿司匹林的抗炎成分，会导致一过性耳鸣和听力损失。全身注射250毫克/公斤的水杨酸盐，这一剂量确实会导致大鼠耳鸣，显著减少大鼠耳蜗声诱发输出。矛盾的是，水杨酸盐显著增加清醒大鼠听皮层(AC)的声诱发电位的幅度，但不增加下丘(IC)的幅度。异氟醚麻醉可增强GABA介导的抑制作用，可使水杨酸引起的AC幅度增加消失，而阻断N-甲基-d-天冬氨酸受体的氯胺酮则进一步增加水杨酸引起的AC幅度增加。但是，直接将水杨酸盐应用于耳蜗处，可降低耳蜗区、IC和AC的反应幅度，提示全身注射水杨酸盐引起的AC波幅增加不是源于耳蜗区。为了确定水杨酸盐诱导的AC增强的行为学相关性，我们测量了水杨酸盐治疗前后的声学惊厥反应。水杨酸盐显著增加了惊吓反应的幅度。总而言之，这些结果表明，高剂量的水杨酸盐增加了中枢听觉系统的增益，可能是通过下调GABA介导的抑制，导致夸大的声学惊吓反应。这种增强的惊吓反应可能是经常伴随耳鸣和听力损失的听觉过敏症的行为相关性。爱思唯尔有限公司代表伊布罗出版。
High doses of salicylate, the anti-inflammatory component of aspirin, induce transient tinnitus and hearing loss. Systemic injection of 250 mg/kg of salicylate, a dose that reliably induces tinnitus in rats, significantly reduced the sound evoked output of the rat cochlea. Paradoxically, salicylate significantly increased the amplitude of the sound-evoked field potential from the auditory cortex (AC) of conscious rats, but not the inferior colliculus (IC). When rats were anesthetized with isoflurane, which increases GABA-mediated inhibition, the salicylate-induced AC amplitude enhancement was abolished, whereas ketamine, which blocks N-methyl-d-aspartate receptors, further increased the salicylate-induced AC amplitude enhancement. Direct application of salicylate to the cochlea, however, reduced the response amplitude of the cochlea, IC and AC, suggesting the AC amplitude enhancement induced by systemic injection of salicylate does not originate from the cochlea. To identify a behavioral correlate of the salicylate-induced AC enhancement, the acoustic startle response was measured before and after salicylate treatment. Salicylate significantly increased the amplitude of the startle response. Collectively, these results suggest that high doses of salicylate increase the gain of the central auditory system, presumably by down-regulating GABA-mediated inhibition, leading to an exaggerated acoustic startle response. The enhanced startle response may be the behavioral correlate of hyperacusis that often accompanies tinnitus and hearing loss. Published by Elsevier Ltd on behalf of IBRO.
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阿司匹林代谢物水杨酸盐通过减少 GABA 能抑制增强大鼠海马 CA1 区神经元兴奋
影响因子：
4.7
作者：
Gong, Neng;Zhang, Min;Xu, Tian-Le
通讯作者：
Xu, Tian-Le
影响因子：
2.8
作者：
Brozoski, TJ;Bauer, CA
通讯作者：
Bauer, CA
DOI：
10.2183/pjab.64.260
发表时间：
1988-10-01
影响因子：
3.1
作者：
HORIKAWA, J;ITO, S;MURATA, K
通讯作者：
MURATA, K
影响因子：
2.5
作者：
JONES, RSG;BUHL, EH
通讯作者：
BUHL, EH
影响因子：
2.8
作者：
FITZGERALD, JJ;ROBERTSON, D;JOHNSTONE, BM
通讯作者：
JOHNSTONE, BM