Recognition and processing of ubiquitin-protein conjugates by the proteasome.
Recognition and processing of ubiquitin-protein conjugates by the proteasome.
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DOI：
10.1146/annurev.biochem.78.081507.101607
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发表时间：
2009
影响因子：
16.6
通讯作者：
Finley D
中科院分区：
文献类型：
--
作者：
Finley D
蛋白酶体是一种复杂的分子机器，它在蛋白质与泛素结合后对其进行降解。底物通过一系列不同的泛素受体在其19个亚基的调节颗粒处与蛋白酶体对接，然后被转运到28个亚基的蛋白水解核心颗粒内的一个内部腔室中，在那里它们被水解。底物通过一个狭窄的有门控的通道被穿入核心颗粒，因此转运需要依赖ATP的底物去折叠。调节颗粒中的六种不同的ATP酶似乎形成一个环形复合物，并驱动去折叠以及转运。底物依赖ATP的、与降解偶联的去泛素化对于有效的底物降解以及抑制泛素降解都是必需的。然而，蛋白酶体也包含在底物降解之前作用于底物的去泛素化酶，从而抑制底物降解。在这里我们研究这个分子机器的关键要素以及它们在蛋白水解底物的加工过程中是如何协作的。
The proteasome is an intricate molecular machine, which serves to degrade proteins following their conjugation to ubiquitin. Substrates dock onto the proteasome at its 19-subunit regulatory particle via a diverse set of ubiquitin receptors, and are then translocated into an internal chamber within the 28-subunit proteolytic core particle, where they are hydrolyzed. Substrate is threaded into the core particle through a narrow gated channel, and thus translocation requires ATP-dependent unfolding of the substrate. Six distinct ATPases in the regulatory particle appear to form a ring complex and to drive unfolding as well as translocation. ATP-dependent, degradation-coupled deubiquitination of the substrate is required both for efficient substrate degradation and for suppressing ubiquitin degradation. However, the proteasome also contains deubiquitinating enzymes that act on substrates prior to degradation, thus suppressing substrate degradation. Here we examine the key elements of this molecular machine and how they cooperate in the processing of proteolytic substrates.
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影响因子：
64.5
作者：
Duda, David M.;Borg, Laura A.;Scott, Daniel C.;Hunt, Harold W.;Hammel, Michal;Schulman, Brenda A.
通讯作者：
Schulman, Brenda A.
影响因子：
4.4
作者：
Barton, LF;Runnels, HA;Monaco, JJ
通讯作者：
Monaco, JJ
DOI：
10.1007/978-1-4020-6554-5_12
发表时间：
2008-01-01
期刊：
PROGRAMMED CELL DEATH IN CANCER PROGRESSION AND THERAPY
影响因子：
--
作者：
Chauhan, Dharminder;Hideshima, Tern;Anderson, Kenneth C.
通讯作者：
Anderson, Kenneth C.
影响因子：
4.8
作者：
Baboshina, OV;Haas, AL
通讯作者：
Haas, AL
影响因子：
16
作者：
Benaroudj, N;Zwickl, P;Goldberg, AL
通讯作者：
Goldberg, AL