Correlation between antibiotic use in childhood and subsequent inflammatory bowel disease: a systematic review and meta-analysis
Correlation between antibiotic use in childhood and subsequent inflammatory bowel disease: a systematic review and meta-analysis
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儿童期抗生素使用与随后的炎症性肠病之间的相关性：系统评价和荟萃分析
DOI：
10.1080/00365521.2020.1737882
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发表时间：
2020-03
影响因子：
1.9
通讯作者：
Yong Xie
中科院分区：
文献类型：
--
作者：
Yunzhi Zou;Lizhi Wu;Wencai Xu;Xiong Zhou;Kun Ye;Huifang Xiong;Conghua Song;Yong Xie
背景：抗生素的使用导致胃肠道炎症反应的级联，因为它与人类微生物群的暂时破坏有关。目的：探讨儿童抗生素使用与随后的炎症性肠病（IBD）之间的未确定相关性。方法：检索PUBMED、EMBASE和Cochrane中央对照试验注册库，查找相关文献。我们提取并汇总（校正）优势比（OR）和（校正）风险比（RR）。结果：本系统综述和荟萃分析包括11项研究。所有11项研究的合并OR为1.5（95%可信区间（CI）： 1.22-1.85）。儿童时期使用抗生素后发生克罗恩病和溃疡性结肠炎的总or分别为1.59 （95% CI: 1.06-2.4）和1.22 （95% CI: 0.82-1.8）。敏感性分析显示无变化。meta回归分析显示，发表年份、研究领域、研究方法差异均无统计学意义。Egger’s检验显示IBD研究的发表偏倚（p = 0.006 < 0.05），但CD研究（p = 0.275 >.05）和UC研究（p = 0.537 >.05）没有发表偏倚。结论：2010-2013年，在西方非欧洲国家，儿童时期抗生素使用与随后发生克罗恩病的风险呈正相关。与欧洲、亚洲和澳大利亚相比，美国儿童服用抗生素后患IBD的风险更高。注册号：CRD42019147648 （PROSPERO）
Abstract Background: Antibiotic use leads to a cascade of inflammatory reaction in the gastrointestinal tract due to its association with a temporary disruption of human microbiome. Objectives: To explore the undetermined correlation between antibiotic use in childhood and subsequent inflammatory bowel disease (IBD). Methods: PUBMED, EMBASE and Cochrane Central Register of Controlled Trials were searched to identify related articles. We extracted and pooled the (adjusted) odds ratio (OR) and (adjusted) risk ratio (RR). Results: This systematic review and meta-analysis included 11 studies. The pooled OR of all 11 studies was 1.5 (95% confidence interval (CI): 1.22–1.85). The pooled ORs of the subsequent Crohn’s disease and ulcerative colitis after antibiotic use in childhood were 1.59 (95% CI: 1.06–2.4) and 1.22 (95% CI: 0.82–1.8). The sensitivity analysis showed no change. The meta-regression showed there was not statistical significance for the publication year, research area and research methods. Egger’s test showed publication bias in the IBD studies (p = .006 < .05) but no publication bias for the CD (p = .275>.05) and UC studies (p = .537>.05). Conclusions: There was a positive association between antibiotic use in childhood and the subsequently risk of Crohn’s disease in non-European countries in the west during 2010–2013. Children in the United States taking antibiotics will have a higher risk of subsequently IBD than Europe, Asia and Australia. Registration number: CRD42019147648 (PROSPERO)
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影响因子：
30.5
作者：
通讯作者：
--
影响因子：
24.5
作者：
Knoop KA;McDonald KG;Kulkarni DH;Newberry RD
通讯作者：
Newberry RD
DOI：
10.1016/s8756-5005(08)70121-5
发表时间：
2007
期刊：
--
影响因子：
--
作者：
C. Hoyen
通讯作者：
C. Hoyen
影响因子：
2.3
作者：
Leong, Rupert W.;Mitrev, Nikola;Ko, Yanna
通讯作者：
Ko, Yanna
影响因子：
5
作者：
Virta, Lauri;Auvinen, Anssi;Kolho, Kaija-Leena
通讯作者：
Kolho, Kaija-Leena