Combined chirp coded tissue harmonic and fundamental ultrasound imaging for intravascular ultrasound: 20-60 MHz phantom and ex vivo results.

Combined chirp coded tissue harmonic and fundamental ultrasound imaging for intravascular ultrasound: 20-60 MHz phantom and ex vivo results.
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DOI:
10.1016/j.ultras.2012.07.003
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发表时间:
2013-02
期刊:
影响因子:
4.2
通讯作者:
Shung, K. Kirk
Shung, K. Kirk
中科院分区:
物理与天体物理2区
文献类型:
--
作者:
Park, Jinhyoung;Li, Xiang;Zhou, Qifa;Shung, K. Kirk

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将线性调频编码激励应用于脉冲反转组织谐波成像,可以提高信噪比。另一方面,在高频血管内超声成像中仍然最普遍的机械扫描器中,由基本信号的泄漏引起的距离旁瓣电平的升高已经成为问题。基波Chirp编码激励成像在Hanning窗下可以获得低于-60 dB的距离旁瓣电平,但其旁瓣电平高于脉冲反转Chirp编码组织谐波成像(PI-CTHI)。因此,本文提出了一种组合脉冲反转啁啾编码组织谐波和基波成像模式(CPI-CTHI),通过展示20-60 MHz体模和离体结果,保留了啁啾编码谐波和基波成像模式的优点。仿真结果表明,在两束脉冲反转对的情况下,假设换能器将入射位置平移50 μm,CPI-CTHI的距离旁瓣电平比PI-CTHI低16 dB。CPI-CTHI实现了一个原型的血管内超声扫描仪,能够组合数据采集实时。线模研究表明,CPI-CTHI的距离旁瓣电平比PI-CTHI低12 dB,回波信噪比高7 dB,而横向分辨率和旁瓣电平分别比基波Chirp编码激发成像细50 μm和小-3dB。兔气管的离体扫描表明,CPI-CTHI能够可视化直径小至200 μm的血管,组织对比度比PI-CTHI或基波啁啾编码激发成像好6 dB。这些结果清楚地表明,CPI-CTHI可以增强组织对比度,而旁瓣水平的范围小于PI-CTHI。
The application of chirp coded excitation to pulse inversion tissue harmonic imaging can increase signal to noise ratio. On the other hand, the elevation of range side lobe level, caused by leakages of the fundamental signal, has been problematic in mechanical scanners which are still the most prevalent in high frequency intravascular ultrasound imaging. Fundamental chirp coded excitation imaging can achieve range side lobe levels lower than –60 dB with Hanning window, but it yields higher side lobes level than pulse inversion chirp coded tissue harmonic imaging (PI-CTHI). Therefore, in this paper a combined pulse inversion chirp coded tissue harmonic and fundamental imaging mode (CPI-CTHI) is proposed to retain the advantages of both chirp coded harmonic and fundamental imaging modes by demonstrating 20–60 MHz phantom and ex vivo results. A simulation study shows that the range side lobe level of CPI-CTHI is 16 dB lower than PI-CTHI, assuming that the transducer translates incident positions by 50 μm when two beamlines of pulse inversion pair are acquired. CPI-CTHI is implemented for a proto-typed intravascular ultrasound scanner capable of combined data acquisition in real-time. A wire phantom study shows that CPI-CTHI has a 12 dB lower range side lobe level and a 7 dB higher echo signal to noise ratio than PI-CTHI, while the lateral resolution and side lobe level are 50 μm finer and –3 dB less than fundamental chirp coded excitation imaging respectively. Ex vivo scanning of a rabbit trachea demonstrates that CPI-CTHI is capable of visualizing blood vessels as small as 200 μm in diameter with 6 dB better tissue contrast than either PI-CTHI or fundamental chirp coded excitation imaging. These results clearly indicate that CPI-CTHI may enhance tissue contrast with less range side lobe level than PI-CTHI.
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