The Role of Nerves in Skeletal Development, Adaptation, and Aging.
The Role of Nerves in Skeletal Development, Adaptation, and Aging.
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DOI：
10.3389/fendo.2020.00646
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发表时间：
2020
影响因子：
5.2
通讯作者：
Genetos DC
中科院分区：
文献类型：
--
作者：
Tomlinson RE;Christiansen BA;Giannone AA;Genetos DC
骨骼的神经支配很好，但直到最近才开始了解骨骼中这种复杂网络的功能。虽然我们的知识骨骼感觉和交感神经支配是不完整的，包括特定的位置和亚型的神经在骨骼中，我们现在能够调和早期的研究利用去神经模型与最近的工作解剖骨和神经之间的分子信号。总的来说，感觉神经支配在骨骼中的功能就像在身体其他地方一样-感知和响应刺激，包括机械负荷。类似地，交感神经调节与骨相关的自主功能，包括稳态重塑和血管张力。然而，需要更多的研究来将我们目前对骨神经串扰的了解转化为新的治疗策略，这些策略可以有效地用于对抗骨骼疾病、低骨量疾病和与年龄相关的骨质量下降。
The skeleton is well-innervated, but only recently have the functions of this complex network in bone started to become known. Although our knowledge of skeletal sensory and sympathetic innervation is incomplete, including the specific locations and subtypes of nerves in bone, we are now able to reconcile early studies utilizing denervation models with recent work dissecting the molecular signaling between bone and nerve. In total, sensory innervation functions in bone much as it does elsewhere in the body—to sense and respond to stimuli, including mechanical loading. Similarly, sympathetic nerves regulate autonomic functions related to bone, including homeostatic remodeling and vascular tone. However, more study is required to translate our current knowledge of bone-nerve crosstalk to novel therapeutic strategies that can be effectively utilized to combat skeletal diseases, disorders of low bone mass, and age-related decreases in bone quality.
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影响因子：
3.3
作者：
Castañeda-Corral G;Jimenez-Andrade JM;Bloom AP;Taylor RN;Mantyh WG;Kaczmarska MJ;Ghilardi JR;Mantyh PW
通讯作者：
Mantyh PW
影响因子：
6.2
作者：
Baek, Kyunghwa;Bloomfield, Susan A.
通讯作者：
Bloomfield, Susan A.
影响因子：
3.3
作者：
Bickel, CS;Slade, JM;Dudley, GA
通讯作者：
Dudley, GA
影响因子：
3.3
作者：
Chartier SR;Mitchell SAT;Majuta LA;Mantyh PW
通讯作者：
Mantyh PW
影响因子：
2.1
作者：
BIDEGAIN, M;ROOS, BA;BALKAN, W
通讯作者：
BALKAN, W