Functional proteomic analysis reveals roles for PKCδ in regulation of cell survival and cell death: Implications for cancer pathogenesis and therapy.
Functional proteomic analysis reveals roles for PKCδ in regulation of cell survival and cell death: Implications for cancer pathogenesis and therapy.
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DOI：
10.1016/j.jbior.2020.100757
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发表时间：
2020-12
影响因子：
--
通讯作者：
Reyland ME
中科院分区：
文献类型：
--
作者：
Speidel JT;Affandi T;Jones DNM;Ferrara SE;Reyland ME
蛋白激酶C-δ（PKCδ）调节广泛的生物学功能和疾病过程，包括在免疫功能、细胞存活和凋亡中的明确作用。PKCδ主要调节正常组织和非转化细胞中的细胞凋亡，并且小鼠中PRKCD基因的遗传破坏在许多疾病和组织损伤模型中具有保护作用。然而，在一些转化细胞和小鼠癌症模型中也描述了促存活/促增殖功能。最近的证据表明，PKCδ对特定癌症的贡献可能部分取决于肿瘤的致癌背景，这与其在细胞存活和细胞死亡中的矛盾作用一致。在这里，我们将讨论什么是目前已知的PKCδ的生物学功能和潜在的范式PKCδ功能在癌症中。为了进一步了解PKCδ的调节机制，并深入了解PKCδ信号传导的可塑性，我们使用功能蛋白质组学来鉴定依赖于PKCδ的通路。了解PKCδ的这些不同功能是如何调节的，对于靶向这一途径的治疗方法的逻辑设计至关重要。
Protein Kinase C-δ (PKCδ), regulates a broad group of biological functions and disease processes, including well-defined roles in immune function, cell survival and apoptosis. PKCδ primarily regulates apoptosis in normal tissues and non-transformed cells, and genetic disruption of the PRKCD gene in mice is protective in many diseases and tissue damage models. However pro-survival/pro-proliferative functions have also been described in some transformed cells and in mouse models of cancer. Recent evidence suggests that the contribution of PKCδ to specific cancers may depend in part on the oncogenic context of the tumor, consistent with its paradoxical role in cell survival and cell death. Here we will discuss what is currently known about biological functions of PKCδ and potential paradigms for PKCδ function in cancer. To further understand mechanisms of regulation by PKCδ, and to gain insight into the plasticity of PKCδ signaling, we have used functional proteomics to identify pathways that are dependent on PKCδ. Understanding how these distinct functions of PKCδ are regulated will be critical for the logical design of therapeutics to target this pathway.
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影响因子：
12.8
作者：
Barr, Paul M.;Lazarus, Hillard M.;Cooper, Brenda W.;Schluchter, Mark D.;Panneerselvam, Ashok;Jacobberger, James W.;Hsu, Jack W.;Janakiraman, Nalini;Simic, Aleksandra;Dowlati, Afshin;Remick, Scot C.
通讯作者：
Remick, Scot C.
影响因子：
64.5
作者：
Antal CE;Hudson AM;Kang E;Zanca C;Wirth C;Stephenson NL;Trotter EW;Gallegos LL;Miller CJ;Furnari FB;Hunter T;Brognard J;Newton AC
通讯作者：
Newton AC
影响因子：
9
作者：
通讯作者：
--
影响因子：
2.9
作者：
Bright, Rachel;Steinberg, Gary K.;Mochly-Rosen, Daria
通讯作者：
Mochly-Rosen, Daria
影响因子：
4
作者：
Berardi, Damian E.;Flumian, Carolina;Todaro, Laura B.
通讯作者：
Todaro, Laura B.