Immunization with dendritic cells can break immunological ignorance toward a persisting virus in the central nervous system and induce partial protection against intracerebral viral challenge.
Immunization with dendritic cells can break immunological ignorance toward a persisting virus in the central nervous system and induce partial protection against intracerebral viral challenge.
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树突状细胞免疫可以打破对中枢神经系统中持续存在的病毒的免疫无知，并诱导针对脑内病毒攻击的部分保护。
DOI：
10.1099/vir.0.80115-0
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
J. Hausmann
中科院分区：
文献类型：
--
作者：
U. Fassnacht;A. Ackermann;P. Staeheli;J. Hausmann
树突状细胞（dc）已被成功地用于诱导CD8 T细胞控制病毒感染和肿瘤的生长。评价dc介导免疫对小鼠嗜神经博纳病病毒（BDV）的控制效果。尽管BDV在大脑中大量复制，但某些品系的小鼠很少发生自发性神经系统疾病。对疾病的抵抗是由于中枢神经系统对BDV抗原的免疫无知。小鼠的无知可以通过免疫包被TELEISSI的dc来打破，TELEISSI是一种从BDV的N蛋白衍生的肽，代表H-2(k)小鼠的免疫优势细胞毒性T淋巴细胞表位。teleisi包被的树突状细胞免疫进一步诱导固体保护性免疫，抵抗表达BDV-N的重组痘苗病毒的静脉攻击。然而，有趣的是，这种免疫方案仅诱导对BDV脑内攻击的中度保护，这表明针对共享抗原产生的免疫记忆可能足以控制外周复制病毒，但不能控制能够避免T细胞激活的高度嗜神经病毒。这种差异可能是由于缺乏BDV特异性CD4 T细胞和/或局部受限BDV感染对dc启动的BDV特异性CD8 T细胞的低效再激活。因此，一种成功的针对具有强嗜神经性的持续性病毒的疫苗可能会诱导抗病毒CD8（以及CD4） T细胞反应，并有利于病毒特异性记忆T细胞在颈部淋巴结的积累。
Dendritic cells (DCs) have been used successfully to induce CD8 T cells that control virus infections and growth of tumours. The efficacy of DC-mediated immunization for the control of neurotropic Borna disease virus (BDV) in mice was evaluated. Certain strains of mice only rarely develop spontaneous neurological disease, despite massive BDV replication in the brain. Resistance to disease is due to immunological ignorance toward BDV antigen in the central nervous system. Ignorance in mice can be broken by immunization with DCs coated with TELEISSI, a peptide derived from the N protein of BDV, which represents the immunodominant cytotoxic T lymphocyte epitope in H-2(k) mice. Immunization with TELEISSI-coated DCs further induced solid protective immunity against intravenous challenge with a recombinant vaccinia virus expressing BDV-N. Interestingly, however, this immunization scheme induced only moderate protection against intracerebral challenge with BDV, suggesting that immune memory raised against a shared antigen may be sufficient to control a peripherally replicating virus, but not a highly neurotropic virus that is able to avoid activation of T cells. This difference might be due to the lack of BDV-specific CD4 T cells and/or inefficient reactivation of DC-primed, BDV-specific CD8 T cells by the locally restricted BDV infection. Thus, a successful vaccine against persistent viruses with strong neurotropism should probably induce antiviral CD8 (as well as CD4) T-cell responses and should favour the accumulation of virus-specific memory T cells in cervical lymph nodes.
影响因子：
56.9
作者：
HUANG, S;HENDRIKS, W;AGUET, M
通讯作者：
AGUET, M
中枢神经系统内的 CTL 效应器功能需要 CD4 T 细胞。
DOI：
--
发表时间：
1998
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Stohlman,SA;Bergmann,CC;Lin,MT;Cua,DJ;Hinton,DR
通讯作者：
Hinton,DR