The pathological and physiological roles of IL-6 amplifier activation.
The pathological and physiological roles of IL-6 amplifier activation.
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DOI：
10.7150/ijbs.4828
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发表时间：
2012
影响因子：
9.2
通讯作者：
Hirano T
中科院分区：
文献类型：
--
作者：
Murakami M;Hirano T
首次发现1型胶原+非免疫细胞（IL-6放大器）中NFκ B触发的IL-6信号传导正反馈环是1型胶原+非免疫细胞中IL-17 A和IL-6刺激后激活的协同信号。随后的疾病模型表明，它也可以通过同时激活NFκB和STAT 3来刺激，作为局部趋化因子诱导剂发挥作用，并作为局部炎症的机制，特别是慢性炎症，如类风湿性关节炎和多发性硬化症。此外，我们最近已经表明，通过局部神经激活的IL-6放大器的过度激活为包括自身反应性T细胞在内的免疫细胞建立了一个通道，以通过第5腰髓背侧血管处的血脑屏障。在这里，我们回顾了IL-6放大器是如何被激活的神经激活和生理相关的网关中枢神经系统。越来越多的证据表明，IL-6放大器为神经激活与炎症性疾病的发展之间的关系提供了潜在的分子机制，这可能会建立一个融合神经学和免疫学的新的交叉学科领域。
The NFκB-triggered positive feedback loop for IL-6 signaling in type 1 collagen+ non-immune cells (IL-6 amplifier) was first discovered to be a synergistic signal that is activated following IL-17A and IL-6 stimulation in type 1 collagen+ non-immune cells. Subsequent disease models have shown that it can also be stimulated by the simultaneous activation of NFκB and STAT3, functions as a local chemokine inducer, and acts as a mechanism for local inflammation, particularly chronic ones like rheumatoid arthritis and a multiple sclerosis. Moreover, we have recently shown that hyper activation of the IL-6 amplifier via regional neural activation establishes a gateway for immune cells including autoreactive T cells to pass the blood-brain barrier at dorsal vessels in 5th lumbar cord. Here we review how the IL-6 amplifier is activated by neural activation and the physiological relevance of the gateway to the central nervous system. Accumulating evidences continues to suggest that the IL-6 amplifier offers a potential molecular mechanism for the relationship between neural activation and the development of inflammatory diseases, which could establish a new interdisciplinary field that fuses neurology and immunology.
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影响因子：
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