Emergent Role of Coronin-1a in Neuronal Signaling.

Emergent Role of Coronin-1a in Neuronal Signaling.
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DOI:
10.1016/bs.vh.2016.10.002
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发表时间:
2017
影响因子:
--
通讯作者:
Deppmann CD
Deppmann CD
中科院分区:
医学4区
文献类型:
--
作者:
Martorella M;Barford K;Winkler B;Deppmann CD

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The Coronin family of proteins were first noted for their role in pathogen–host interactions and for modulating actin dynamics. Recently, however, Coronins have been found in a greater variety of cell types, and novel roles for the Coronins within the nervous system have been discovered. In the immune system, Coronin-1a enables Mycobacterium tuberculosis to evade lysosomal destruction. This activity appears to be analogous to protection of the NGF–TrkA signaling endosome during sympathetic nervous system development that is required for survival signaling. Similarly, others have implicated Coronin-1a in GPCR signaling during the formation of excitatory connections in the central nervous system. Its role in multiple signaling pathways suggests that it may influence cross talk between key pathways (TrkA, GPCRs) during neurodevelopment. Here, we review the role of Coronin-1a in neural development and function.
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