The red death meets the abdominal bristle: polygenic mutation for susceptibility to a bacterial pathogen in Caenorhabditis elegans.
The red death meets the abdominal bristle: polygenic mutation for susceptibility to a bacterial pathogen in Caenorhabditis elegans.
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红色死亡遇到了腹猪：秀丽隐杆线虫中细菌病原体敏感的多基因突变。
DOI：
10.1111/evo.12585
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发表时间：
2015-02
期刊：
影响因子：
--
通讯作者：
Baer CF
中科院分区：
文献类型：
--
作者：
Etienne V;Andersen EC;Ponciano JM;Blanton D;Cadavid A;Joyner-Matos J;Matsuba C;Tabman B;Baer CF
Understanding the genetic basis of susceptibility to pathogens is an important goal of medicine and of evolutionary biology. A key first step toward understanding the genetics and evolution of any phenotypic trait is characterizing the role of mutation. However, the rate at which mutation introduces genetic variance for pathogen susceptibility in any organism is essentially unknown. Here we quantify the per-generation input of genetic variance by mutation (VM) for susceptibility of Caenorhabditis elegans to the pathogenic bacterium Pseudomonas aeruginosa (defined as the median time of death, LT50). VM for LT50 is slightly less than VM for a variety of life-history and morphological traits in this strain of C. elegans, but is well within the range of reported values in a variety of organisms. Mean LT50 did not change significantly over 250 generations of mutation accumulation. Comparison of VM to the standing genetic variance (VG) implies a strength of selection against new mutations of a few tenths of a percent. These results suggest that the substantial standing genetic variation for susceptibility of C. elegans to P. aeruginosa can be explained by polygenic mutation coupled with purifying selection.
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影响因子：
30.8
作者：
Andersen, Erik C.;Gerke, Justin P.;Shapiro, Joshua A.;Crissman, Jonathan R.;Ghosh, Rajarshi;Bloom, Joshua S.;Felix, Marie-Anne;Kruglyak, Leonid
通讯作者：
Kruglyak, Leonid
影响因子：
64.8
作者：
Chang, Howard C.;Paek, Jennifer;Kim, Dennis H.
通讯作者：
Kim, Dennis H.
DOI：
10.1093/gerona/glp112
发表时间：
2009-11-01
影响因子：
5.1
作者：
Joyner-Matos, Joanna;Upadhyay, Ambuj;Baer, Charles F.
通讯作者：
Baer, Charles F.
影响因子：
1.9
作者：
Kenward, MG;Roger, JH
通讯作者：
Roger, JH
DOI：
10.1073/pnas.0406056102
发表时间：
2005-04-19
影响因子：
11.1
作者：
Baer, CF;Shaw, F;Lynch, M
通讯作者：
Lynch, M