Hyperthermia and thermosensitive liposomes for improved delivery of chemotherapeutic drugs to solid tumors.
Hyperthermia and thermosensitive liposomes for improved delivery of chemotherapeutic drugs to solid tumors.
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DOI：
10.1007/s11095-010-0154-2
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发表时间：
2010-08
影响因子：
3.7
通讯作者：
ten Hagen, Timo L. M.
中科院分区：
文献类型：
--
作者：
Koning, Gerben A.;Eggermont, Alexander M. M.;Lindner, Lars H.;ten Hagen, Timo L. M.
基于脂质的纳米载体或脂质体已被证明在递送化疗剂方面是成功的，并且目前在临床上应用于治疗各种类型的癌症。脂质体提供了高药物有效载荷、降低药物毒性和增强药物在肿瘤部位积聚的优点。增加的蓄积是由于相对渗漏的肿瘤脉管系统允许脂质体外渗。在不同类型的肿瘤之间，甚至在一个肿瘤内，血管渗透性和因此脂质体外渗可能差异很大。此外，当脂质体在肿瘤区域中积累时，不能保证药物生物利用度。这些是目前临床应用的脂质体药物所面临的主要问题。轻度热疗（HT），将肿瘤组织加热至高达43°C的温度，在过去几十年中已发展为与化疗和放疗相结合的既定有效治疗方式。HT可用于以两种方式进一步改善脂质体化疗：已知HT可增加实体瘤中的血管通透性，因此可增加脂质体积累的水平，并且已经开发出热敏脂质体，其可在高热时触发释放其内容物。通过应用这两种策略，可以大大增强向肿瘤的药物递送。
Lipid-based nanocarriers or liposomes have been proven successful in the delivery of chemotherapeutic agents and are currently applied clinically in the treatment of various types of cancer. Liposomes offer the advantage of a high drug payload, decreased drug toxicity and enhanced drug accumulation at tumor sites. Increased accumulation is due to the relatively leaky tumor vasculature that allows liposome extravasation. Between different types of tumors and even within one tumor, vascular permeability and thus liposome extravasation may differ greatly. Furthermore, upon accumulation of liposomes in the tumor area, drug bioavailability is not guaranteed. At present, these are the major issues for clinically used liposomal drugs. Mild hyperthermia (HT), the heating of tumor tissue to temperatures of up to 43°C, has been developed in the past decades as an established and efficacious treatment modality in combination with chemo- and radiotherapy. HT can be used to further improve liposomal chemotherapy in two ways: HT is known to increase vascular permeability in solid tumors and may therefore increase levels of liposome accumulation, and thermosensitive liposomes have been developed that can be triggered to release their contents upon hyperthermia. By applying these two strategies, drug delivery to tumors can be strongly enhanced.
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影响因子：
56.9
作者：
YATVIN, MB;WEINSTEIN, JN;BLUMENTHAL, R
通讯作者：
BLUMENTHAL, R
影响因子：
3.1
作者：
Franckena, Martine;De Wit, Ronald;Van der Zee, Jacoba
通讯作者：
Van der Zee, Jacoba
DOI：
10.1093/jnci/djk005
发表时间：
2007-01-03
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Ponce, Ana M.;Viglianti, Benjamin L.;Dewhirst, Mark W.
通讯作者：
Dewhirst, Mark W.
影响因子：
11.2
作者：
Seynhaeve, Ann L. B.;Hoving, Saske;ten Hagen, Timo L. M.
通讯作者：
ten Hagen, Timo L. M.
影响因子：
11.5
作者：
Lindner, LH;Eichhorn, ME;Dellian, M
通讯作者：
Dellian, M