Metabolic and chaperone gene loss marks the origin of animals: evidence for Hsp104 and Hsp78 chaperones sharing mitochondrial enzymes as clients.
Metabolic and chaperone gene loss marks the origin of animals: evidence for Hsp104 and Hsp78 chaperones sharing mitochondrial enzymes as clients.
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DOI：
10.1371/journal.pone.0117192
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Fassler JS
中科院分区：
文献类型：
--
作者：
Erives AJ;Fassler JS
动物的进化涉及获得一种用于原肠形成的新兴基因库。基因丢失是否也与这种发育性重编程共同进化还没有得到解决。在这里，我们确定了二十四种遗传功能，这些功能保留在真菌和鞭藻中，但在动物中无法检测到。这些丢失的基因编码：(1)16种不同的生物合成功能；（ii）两种原始的真核ClpB分解气体Hsp78和Hsp104，分别在线粒体和细胞质中起作用；（三）其他六项配套功能。我们提出的计算和实验数据与差异定位的ClpB分解气体的联合功能一致，并且与丢失的LYS4基因编码的线粒体Fe/S同形乌头酶与两个ClpB之间共享客户/伴侣关系的可能性一致。我们的分析得出一个假设，即动物以原肠胚为基础的多细胞进化导致了从膳食来源中有效地提取营养物质，失去了维持能量昂贵的生物合成途径的自然选择，以及随后伴随的ClpB伴侣的丧失。
The evolution of animals involved acquisition of an emergent gene repertoire for gastrulation. Whether loss of genes also co-evolved with this developmental reprogramming has not yet been addressed. Here, we identify twenty-four genetic functions that are retained in fungi and choanoflagellates but undetectable in animals. These lost genes encode: (i) sixteen distinct biosynthetic functions; (ii) the two ancestral eukaryotic ClpB disaggregases, Hsp78 and Hsp104, which function in the mitochondria and cytosol, respectively; and (iii) six other assorted functions. We present computational and experimental data that are consistent with a joint function for the differentially localized ClpB disaggregases, and with the possibility of a shared client/chaperone relationship between the mitochondrial Fe/S homoaconitase encoded by the lost LYS4 gene and the two ClpBs. Our analyses lead to the hypothesis that the evolution of gastrulation-based multicellularity in animals led to efficient extraction of nutrients from dietary sources, loss of natural selection for maintenance of energetically expensive biosynthetic pathways, and subsequent loss of their attendant ClpB chaperones.
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DOI：
10.1093/bioinformatics/8.3.275
发表时间：
1992-06-01
期刊：
COMPUTER APPLICATIONS IN THE BIOSCIENCES
影响因子：
--
作者：
JONES, DT;TAYLOR, WR;THORNTON, JM
通讯作者：
THORNTON, JM
影响因子：
12.3
作者：
Fairclough SR;Chen Z;Kramer E;Zeng Q;Young S;Robertson HM;Begovic E;Richter DJ;Russ C;Westbrook MJ;Manning G;Lang BF;Haas B;Nusbaum C;King N
通讯作者：
King N
影响因子：
64.5
作者：
DeSantis ME;Leung EH;Sweeny EA;Jackrel ME;Cushman-Nick M;Neuhaus-Follini A;Vashist S;Sochor MA;Knight MN;Shorter J
通讯作者：
Shorter J
影响因子：
5.8
作者：
Hibbs, Matthew A.;Hess, David C.;Troyanskaya, Olga G.
通讯作者：
Troyanskaya, Olga G.
影响因子：
2.6
作者：
Degnan, BM;Leys, SP;Larroux, C
通讯作者：
Larroux, C