SoxE factors as multifunctional neural crest regulatory factors.
SoxE factors as multifunctional neural crest regulatory factors.
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DOI：
10.1016/j.biocel.2009.11.014
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发表时间：
2010-03
影响因子：
4
通讯作者：
LaBonne, Carole
中科院分区：
文献类型：
--
作者：
Haldin, Caroline E.;LaBonne, Carole
神经脊细胞是导致脊椎动物进化的主要创新，而SoxE家族的转录因子(Sox8、Sox9和Sox10)是调节这些细胞发育的中心角色。到目前为止，在所有被研究的脊椎动物中，一个或多个SoxE蛋白是形成神经脊细胞、维持其多能性和生存所必需的。后来，SoxE蛋白驱动多种神经脊衍生物的形成，包括软骨细胞、黑素细胞和周围神经系统细胞，特别是雪旺细胞/周围神经胶质细胞。鉴于SoxE因子在神经脊发育中的多种不同作用，了解SoxE因子的活性是如何控制的，从而指导正确的发育结果是很重要的。虽然与其他调节因子的组合控制显然是产生这种功能多样性的一种机制，但SoxD家族因子和翻译后修饰对SoxE活性的调节似乎也很重要。阐明控制SoxE功能的机制对于了解脊椎动物的进化起源以及一系列与SoxE相关的综合征和疾病至关重要，并可能被证明对开发针对SoxE调节细胞类型的基于干细胞的疗法至关重要。
Neural crest cells are the primary innovation that led to evolution of the vertebrates, and transcription factors of the SoxE family (Sox8, Sox9 and Sox10) are among the central players regulating the development of these cells. In all vertebrates examined to date, one or more SoxE proteins are required for the formation of neural crest cells, the maintenance of their multipotency, and their survival. Later, SoxE proteins drive the formation of multiple neural crest derivatives including chondrocytes, melanocytes, and cells of the peripheral nervous system, particularly Schwann cells/peripheral glia. Given their multiple diverse roles in the development of the neural crest, it is important to understand how the activity of SoxE factors is controlled such that they direct the correct developmental outcome. While combinatorial control with other regulatory factors is clearly one mechanism for generating such functional versatility, modulation of SoxE activity, both by SoxD family factors and by post-translational modification, also appears to be important. Elucidating the mechanisms that control SoxE function is essential to understanding the evolutionary origin of the vertebrates, as well as a host of SoxE-linked syndromes and diseases, and may prove crucial for developing stem cell based therapies that target SoxE-regulated cell types.
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影响因子：
11.4
作者：
Lefebvre, V;Li, P;de Crombrugghe, B
通讯作者：
de Crombrugghe, B
影响因子：
10.5
作者：
Akiyama, H;Chaboissier, MC;de Crombrugghe, B
通讯作者：
de Crombrugghe, B
影响因子：
11.4
作者：
Malki, S;Nef, S;Boizet-Bonhoure, B
通讯作者：
Boizet-Bonhoure, B
DOI：
10.1111/j.1749-6632.1996.tb56252.x
发表时间：
1996-01-01
期刊：
MOLECULAR AND DEVELOPMENTAL BIOLOGY OF CARTILAGE
影响因子：
--
作者：
Schafer, AJ;Foster, JW;Goodfellow, PN
通讯作者：
Goodfellow, PN
影响因子：
4.6
作者：
Elworthy, S;Lister, JA;Kelsh, RN
通讯作者：
Kelsh, RN