Centromere remodeling in Hoolock leuconedys (Hylobatidae) by a new transposable element unique to the gibbons.
Centromere remodeling in Hoolock leuconedys (Hylobatidae) by a new transposable element unique to the gibbons.
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DOI：
10.1093/gbe/evs048
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发表时间：
2012
影响因子：
3.3
通讯作者：
de Jong PJ
中科院分区：
文献类型：
--
作者：
Carbone L;Harris RA;Mootnick AR;Milosavljevic A;Martin DI;Rocchi M;Capozzi O;Archidiacono N;Konkel MK;Walker JA;Batzer MA;de Jong PJ
仅在 15-1800 万年前，长臂猿（Hylobatidae）与其他类人猿有着共同的祖先。然而，长臂猿表现出非常独特的特征，包括严重重新排列的染色体。先前的观察表明，这种现象可能与长臂猿物种中转座元件（TE）的表观遗传抑制减弱有关。在这里，我们描述了东部白眉长臂猿（Hoolock leuconedys）几乎所有着丝粒中重复的大规模扩张。我们发现这个重复是一种新的复合TE，源自其他三种元素（L1ME5、AluSz6 和SVA_A）的部分组合，因此将其命名为LAVA。我们确定这种重复现象存在于所有长臂猿中，但不会发生在其他类人猿中。对 46 个不同 LAVA 元件的详细研究表明，其中大多数具有靶位点重复 (TSD) 和多聚腺苷酸尾巴，表明它们在长臂猿基因组中进行了逆转录转座。尽管我们没有发现LAVA元件的出现与人类-长臂猿同线性断点之间存在直接关联，但这种新的复合转座元件是长臂猿基因组巨大可塑性的另一个标志。此外，白眉中 LAVA 插入的着丝粒扩张与袋鼠（有袋类）种间杂交种报道的 KERV-1 逆转录元件的大规模着丝粒扩张非常相似。这两种现象之间的相似性与长臂猿进化的特征是 TE 表观遗传抑制缺陷的假设是一致的，这可能是由种间杂交引发的。
Gibbons (Hylobatidae) shared a common ancestor with the other hominoids only 15–18 million years ago. Nevertheless, gibbons show very distinctive features that include heavily rearranged chromosomes. Previous observations indicate that this phenomenon may be linked to the attenuated epigenetic repression of transposable elements (TEs) in gibbon species. Here we describe the massive expansion of a repeat in almost all the centromeres of the eastern hoolock gibbon (Hoolock leuconedys). We discovered that this repeat is a new composite TE originating from the combination of portions of three other elements (L1ME5, AluSz6, and SVA_A) and thus named it LAVA. We determined that this repeat is found in all the gibbons but does not occur in other hominoids. Detailed investigation of 46 different LAVA elements revealed that the majority of them have target site duplications (TSDs) and a poly-A tail, suggesting that they have been retrotransposing in the gibbon genome. Although we did not find a direct correlation between the emergence of LAVA elements and human–gibbon synteny breakpoints, this new composite transposable element is another mark of the great plasticity of the gibbon genome. Moreover, the centromeric expansion of LAVA insertions in the hoolock closely resembles the massive centromeric expansion of the KERV-1 retroelement reported for wallaby (marsupial) interspecific hybrids. The similarity between the two phenomena is consistent with the hypothesis that evolution of the gibbons is characterized by defects in epigenetic repression of TEs, perhaps triggered by interspecific hybridization.
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影响因子：
4.5
作者：
de Koning AP;Gu W;Castoe TA;Batzer MA;Pollock DD
通讯作者：
Pollock DD
影响因子：
10.7
作者：
Cellamare，A.;Catacchio，C. R.;Ventura，M.
通讯作者：
Ventura，M.
影响因子：
4.5
作者：
Carbone L;Harris RA;Vessere GM;Mootnick AR;Humphray S;Rogers J;Kim SK;Wall JD;Martin D;Jurka J;Milosavljevic A;de Jong PJ
通讯作者：
de Jong PJ
影响因子：
64.8
作者：
Locke, Devin P.;Hillier, LaDeana W.;Warren, Wesley C.;Worley, Kim C.;Nazareth, Lynne V.;Muzny, Donna M.;Yang, Shiaw-Pyng;Wang, Zhengyuan;Chinwalla, Asif T.;Minx, Pat;Mitreva, Makedonka;Cook, Lisa;Delehaunty, Kim D.;Fronick, Catrina;Schmidt, Heather;Fulton, Lucinda A.;Fulton, Robert S.;Nelson, Joanne O.;Magrini, Vincent;Pohl, Craig;Graves, Tina A.;Markovic, Chris;Cree, Andy;Dinh, Huyen H.;Hume, Jennifer;Kovar, Christie L.;Fowler, Gerald R.;Lunter, Gerton;Meader, Stephen;Heger, Andreas;Ponting, Chris P.;Marques-Bonet, Tomas;Alkan, Can;Chen, Lin;Cheng, Ze;Kidd, Jeffrey M.;Eichler, Evan E.;White, Simon;Searle, Stephen;Vilella, Albert J.;Chen, Yuan;Flicek, Paul;Ma, Jian;Raney, Brian;Suh, Bernard;Burhans, Richard;Herrero, Javier;Haussler, David;Faria, Rui;Fernando, Olga;Darre, Fleur;Farre, Domenec;Gazave, Elodie;Oliva, Meritxell;Navarro, Arcadi;Roberto, Roberta;Capozzi, Oronzo;Archidiacono, Nicoletta;Della Valle, Giuliano;Purgato, Stefania;Rocchi, Mariano;Konkel, Miriam K.;Walker, Jerilyn A.;Ullmer, Brygg;Batzer, Mark A.;Smit, Arian F. A.;Hubley, Robert;Casola, Claudio;Schrider, Daniel R.;Hahn, Matthew W.;Quesada, Victor;Puente, Xose S.;Ordonez, Gonzalo R.;Lopez-Otin, Carlos;Vinar, Tomas;Brejova, Brona;Ratan, Aakrosh;Harris, Robert S.;Miller, Webb;Kosiol, Carolin;Lawson, Heather A.;Taliwal, Vikas;Martins, Andre L.;Siepel, Adam;RoyChoudhury, Arindam;Ma, Xin;Degenhardt, Jeremiah;Bustamante, Carlos D.;Gutenkunst, Ryan N.;Mailund, Thomas;Dutheil, Julien Y.;Hobolth, Asger;Schierup, Mikkel H.;Ryder, Oliver A.;Yoshinaga, Yuko;de Jong, Pieter J.;Weinstock, George M.;Rogers, Jeffrey;Mardis, Elaine R.;Gibbs, Richard A.;Wilson, Richard K.
通讯作者：
Wilson, Richard K.
影响因子：
1.6
作者：
Carone, Dawn M.;Longo, Mark S.;O'Neill, Rachel J.
通讯作者：
O'Neill, Rachel J.