Office-Based Methadone Treatment for Opioid Use Disorder and Pharmacy Dispensing: A Scoping Review.
Office-Based Methadone Treatment for Opioid Use Disorder and Pharmacy Dispensing: A Scoping Review.
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DOI：
10.1176/appi.ajp.2021.20101548
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发表时间：
2021-09-01
期刊：
影响因子：
--
通讯作者：
Chou R
中科院分区：
文献类型：
--
作者：
McCarty D;Bougatsos C;Chan B;Hoffman KA;Priest KC;Grusing S;Chou R
一项范围审查调查了评估在办公室环境中使用美沙酮治疗阿片类药物使用障碍（OUD）患者的结果的研究的证据景观。检索了奥维德MEDLINE和科克伦系统评价数据库，并对参考文献列表进行了审查，以确定其他研究。如果研究的重点是在美国或其他高度发达国家进行的基于办公室的美沙酮治疗，并报告了结果（例如，保持护理）。优先考虑随机试验和对照观察性研究;当没有更有力的证据时，纳入非对照和描述性研究。一位研究者提取关键信息;第二位验证数据。范围审查方法广泛调查了证据;因此，研究质量没有正式评级。我们确定了17项针对接受办公室美沙酮治疗的患者的研究，包括6项试验、7项观察性研究和4篇讨论使用药房分发美沙酮的额外论文。对基于办公室的美沙酮（包括基于初级保健的配药）的研究有限，但一致发现，稳定的美沙酮患者重视基于办公室的护理，保持在药物使用率低的护理中;与常规护理中的稳定患者相比，结果相似。基于美沙酮的美沙酮与更高的治疗满意度和生活质量相关。局限性包括对比力度不足和样本量小。有限的研究表明，基于办公室的美沙酮和药房配药可以提高获得美沙酮治疗的OUD患者，而不会对患者的结果产生不利影响，并可能通知修改联邦法规。研究应评估对不太稳定的患者进行基于办公室的护理的可行性。
A scoping review surveyed the evidence landscape for studies that assessed outcomes of treating opioid use disorder (OUD) patients with methadone in office-based settings. Ovid MEDLINE and the Cochrane Database of Systematic Reviews databases were searched and reference lists were reviewed to identify additional studies. Studies were eligible if they focused on methadone treatment in office-based settings conducted in the United States or other highly developed countries and reported outcomes (e.g., retention in care). Randomized trials and controlled observational studies were prioritized; uncontrolled and descriptive studies were included when stronger evidence was unavailable. One investigator abstracted key information; a second verified data. A scoping review approach broadly surveyed the evidence; study quality, therefore, was not rated formally. We identified 17 studies of patients treated with office-based methadone, including 6 trials, 7 observational studies, and 4 additional papers discussing use of pharmacies to dispense methadone. Studies on office-based methadone, including primary care-based dispensing, were limited but consistently found that stable methadone patients valued office-based care, remained in care with low rates of drug use; outcomes were similar compared to stable patients in regular care. Office-based methadone was associated with higher treatment satisfaction and quality of life. Limitations include underpowered comparisons and small samples. Limited research suggests that office-based methadone and pharmacy dispensing could enhance access to methadone treatment for patients with OUD without adversely impacting patient outcomes, and, potentially, inform modifications to federal regulations. Research should assess the feasibility of office-based care for less stable patients.
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影响因子：
4.2
作者：
Joudrey PJ;Chadi N;Roy P;Morford KL;Bach P;Kimmel S;Wang EA;Calcaterra SL
通讯作者：
Calcaterra SL
影响因子：
1.1
作者：
Drucker, Ernest;Rice, Sam;Tuchman, Ellen
通讯作者：
Tuchman, Ellen
影响因子：
3.9
作者：
Gossop, M;Stewart, D;Marsden, J
通讯作者：
Marsden, J
影响因子：
3.9
作者：
Miele, Gloria M.;Caton, Lauren;Rawson, Richard
通讯作者：
Rawson, Richard
DOI：
10.1111/add.15087
发表时间：
2020-12
期刊：
Addiction (Abingdon, England)
影响因子：
--
作者：
Jin H;Marshall BDL;Degenhardt L;Strang J;Hickman M;Fiellin DA;Ali R;Bruneau J;Larney S
通讯作者：
Larney S