Single-Shot Vaccines against Bovine Respiratory Syncytial Virus (BRSV): Comparative Evaluation of Long-Term Protection after Immunization in the Presence of BRSV-Specific Maternal Antibodies.
Single-Shot Vaccines against Bovine Respiratory Syncytial Virus (BRSV): Comparative Evaluation of Long-Term Protection after Immunization in the Presence of BRSV-Specific Maternal Antibodies.
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DOI：
10.3390/vaccines9030236
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发表时间：
2021-03-09
期刊：
影响因子：
7.8
通讯作者：
Riffault S
中科院分区：
文献类型：
--
作者：
Valarcher JF;Hägglund S;Näslund K;Jouneau L;Malmström E;Boulesteix O;Pinard A;Leguéré D;Deslis A;Gauthier D;Dubuquoy C;Pietralunga V;Rémot A;Falk A;Shevchenko G;Bergström Lind S;Von Brömssen C;Vargmar K;Zhang B;Kwong PD;Rodriguez MJ;Garcia Duran M;Schwartz-Cornil I;Taylor G;Riffault S
成功的牛呼吸道合胞病毒（BRSV）疫苗接种计划需要诱导出持久的临床和病毒学保护。在这项研究中，具有BRSV特异性母源抗体的小牛接受了一次疫苗接种，接种情况分别为：（i）BRSV预融合蛋白（PreF）和MontanideTM ISA61 VG（ISA61组，n = 6）；（ii）缺失SH基因的BRSV（ΔSHrBRSV组，n = 6）；（iii）一种商业疫苗（CV组，n = 6）；或者仅注射ISA61（对照组，n = 6）。所有小牛在92天后用BRSV进行攻毒，并在感染13天后实施安乐死。基于临床、病理和蛋白质组学数据，所有疫苗似乎都是安全的。与对照组相比，PreF在攻毒后诱导出最显著的临床和病毒学保护，其次是ΔSHrBRSV和CV，而PreF疫苗接种的小牛所受保护与接种疫苗84天后的BRSV特异性血清免疫球蛋白（Ig）G抗体反应相关，并且ΔSHrBRSV和CV疫苗接种的小牛在这一天的IgG抗体滴度与对照组无差异。然而，在BRSV攻毒后，接种任何一种疫苗的小牛都出现了强烈的回忆性BRSV和PreF特异性IgG反应。总之，PreF和ΔSHrBRSV是两种有效的单次接种候选疫苗。通过诱导至少三个月的保护，它们有可能改善小牛中BRSV的防控。
The induction of long-lasting clinical and virological protection is needed for a successful vaccination program against the bovine respiratory syncytial virus (BRSV). In this study, calves with BRSV-specific maternally derived antibodies were vaccinated once, either with (i) a BRSV pre-fusion protein (PreF) and MontanideTM ISA61 VG (ISA61, n = 6), (ii) BRSV lacking the SH gene (ΔSHrBRSV, n = 6), (iii) a commercial vaccine (CV, n = 6), or were injected with ISA61 alone (n = 6). All calves were challenged with BRSV 92 days later and were euthanized 13 days post-infection. Based on clinical, pathological, and proteomic data, all vaccines appeared safe. Compared to the controls, PreF induced the most significant clinical and virological protection post-challenge, followed by ΔSHrBRSV and CV, whereas the protection of PreF-vaccinated calves was correlated with BRSV-specific serum immunoglobulin (Ig)G antibody responses 84 days post-vaccination, and the IgG antibody titers of ΔSHrBRSV- and CV-vaccinated calves did not differ from the controls on this day. Nevertheless, strong anamnestic BRSV- and PreF-specific IgG responses occurred in calves vaccinated with either of the vaccines, following a BRSV challenge. In conclusion, PreF and ΔSHrBRSV are two efficient one-shot candidate vaccines. By inducing a protection for at least three months, they could potentially improve the control of BRSV in calves.
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影响因子：
5.5
作者：
Hägglund S;Hu K;Vargmar K;Poré L;Olofson AS;Blodörn K;Anderson J;Ahooghalandari P;Pringle J;Taylor G;Valarcher JF
通讯作者：
Valarcher JF
影响因子：
2.6
作者：
Blodörn K;Hägglund S;Gavier-Widen D;Eléouët JF;Riffault S;Pringle J;Taylor G;Valarcher JF
通讯作者：
Valarcher JF
DOI：
10.4049/jimmunol.181.10.6692
发表时间：
2008-11-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Castilow EM;Legge KL;Varga SM
通讯作者：
Varga SM
DOI：
10.1073/pnas.1222342110
发表时间：
2013-02-26
影响因子：
11.1
作者：
Boyle, Louise H.;Hermann, Clemens;Trowsdale, John
通讯作者：
Trowsdale, John
影响因子：
3.7
作者：
Chhikara N;Saraswat M;Tomar AK;Dey S;Singh S;Yadav S
通讯作者：
Yadav S