Contractile function of the cervix plays a role in normal and pathological pregnancy and parturition.
Contractile function of the cervix plays a role in normal and pathological pregnancy and parturition.
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DOI：
10.1016/j.mehy.2020.110336
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发表时间：
2020-12
影响因子：
4.7
通讯作者：
Menon R
中科院分区：
文献类型：
--
作者：
Tantengco OAG;Menon R
宫颈在确保正确的怀孕和分娩时间方面起着不可或缺的作用。它将胎儿留在子宫内，并保护它免受阴道内存在的病原体的侵袭。在怀孕和分娩期间，宫颈经历了广泛的重塑。这一过程与胶原降解、免疫细胞反应增加和宫颈炎症有关。然而，我们对宫颈平滑肌的作用及其在宫颈重塑中的作用仍缺乏了解。在本文中，我们认为宫颈的主动收缩功能在妊娠和分娩期间影响宫颈重塑。宫颈平滑肌肉的收缩有助于在怀孕早期保持宫颈的坚固和闭合，而宫颈平滑肌肉的放松有助于在分娩期间宫颈扩张。宫颈的这种收缩功能可能受到内分泌信号的影响，如雌激素、孕酮和催产素；局部旁分泌信号，如炎性化学因子和细胞因子，以及细胞外小泡，如外体和外体；以及用于宫颈成熟和引产的药物。深入了解子宫颈平滑肌在宫颈重塑中的作用，有助于我们阐明妊娠和分娩过程中宫颈的细胞过程。这也有助于在宫颈中找到关键的信号通路和治疗靶点，从而降低宫颈早熟和早产的发生率。
The cervix plays an integral part in ensuring the proper timing of pregnancy and parturition. It maintains the fetus within the uterus and protects it from pathogens present in the vaginal canal. The cervix undergoes extensive remodeling during pregnancy and parturition. This process is associated with collagen degradation, an increase in immune cell response and inflammation in the cervix. However, our understanding of the role of cervical smooth muscles and their contribution to cervical remodeling is still lacking. In this paper, we propose that the active contractile function of the cervix influences cervical remodeling during pregnancy and parturition. Contraction of the cervical smooth muscles helps the cervix to remain firm and closed during early pregnancy, while relaxation of the cervical smooth muscles help facilitate cervical dilatation during labor. This contractile function of the cervix can be influenced by endocrine signals, such as estrogen, progesterone, and oxytocin; local paracrine signals, such as inflammatory chemokines and cytokines, as well as extracellular vesicles, such as exosomes and ectosomes; and by pharmacological agents used for cervical ripening and the induction of labor. A deeper understanding of the role of smooth muscles in cervical remodeling can help us elucidate the cellular processes in the cervix during pregnancy and parturition. This can also help in finding critical signaling pathways and therapeutic targets in the cervix that may decrease the rates of premature cervical ripening and preterm birth.
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DOI：
10.1016/s1701-2163(15)30842-2
发表时间：
2013-09-01
影响因子：
1.8
作者：
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Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
影响因子：
7.2
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