Muscle stem cells get a new look: Dynamic cellular projections as sensors of the stem cell niche.
Muscle stem cells get a new look: Dynamic cellular projections as sensors of the stem cell niche.
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DOI：
10.1002/bies.202200249
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发表时间：
2023-05
期刊：
影响因子：
4
通讯作者：
Kann, Allison P.
中科院分区：
文献类型：
--
作者：
Krauss, Robert S.;Kann, Allison P.
静止干细胞感知组织损伤并转变为激活状态的细胞机制在很大程度上是未知的。静止的骨骼肌干细胞（MuSC，也称为卫星细胞）具有精细的、异质的突起，其响应于肌肉损伤而迅速收缩。因此，它们可以作为其生态位环境的直接传感器。回缩由Rac至Rho GTdR活性开关驱动，其促进下游MuSC激活事件。这些和其他观察导致了几个假设：（1）投射在静止时是形态学上动态的，为肌肉损伤提供了监视功能;（2）静止投射动态受小生境来源的线索促进的Rac和Rho活动的相对平衡调节;（3）突起，特别是其相关的丝状伪足，通过龛的生物力学性质的变化和/或检测由受损肌纤维释放的信号线索来感测组织损伤;以及（4）投射的动态性质导致具有异质功能特性的MuSC群体。这些概念可以扩展到其他类型的静止干细胞，以及证明在转化研究环境中是有用的。
Cellular mechanisms whereby quiescent stem cells sense tissue injury and transition to an activated state are largely unknown. Quiescent skeletal muscle stem cells (MuSCs, also called satellite cells) have elaborate, heterogeneous projections that rapidly retract in response to muscle injury. They may therefore act as direct sensors of their niche environment. Retraction is driven by a Rac-to-Rho GTPase activity switch that promotes downstream MuSC activation events. These and other observations lead to several hypotheses: (1) projections are morphologically dynamic at quiescence, providing a surveillance function for muscle damage; (2) quiescent projection dynamics are regulated by the relative balance of Rac and Rho activities promoted by niche-derived cues; (3) projections, particularly their associated filopodia, sense tissue damage via changes to the biomechanical properties of the niche and/or detection of signaling cues released by damaged myofibers; and (4) the dynamic nature of projections results in a population of MuSCs with heterogeneous functional properties. These concepts may extend to other types of quiescent stem cells, as well as prove useful in translational research settings.
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DOI：
10.1242/dev.100842
发表时间：
2014-04
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Chakkalakal JV;Christensen J;Xiang W;Tierney MT;Boscolo FS;Sacco A;Brack AS
通讯作者：
Brack AS
影响因子：
7.7
作者：
Jacques, Erik;Kuang, Yinni;Kann, Allison P.;Le Grand, Fabien;Krauss, Robert S.;Gilbert, Penney M.
通讯作者：
Gilbert, Penney M.
影响因子：
3.2
作者：
Arjonen, Antti;Kaukonen, Riina;Ivaska, Johanna
通讯作者：
Ivaska, Johanna
影响因子：
8.8
作者：
Almada, Albert E.;Horwitz, Naftali;Price, Feodor D.;Gonzalez, Alfredo E.;Ko, Michelle;Bolukbasi, Ozge Vargel;Messemer, Kathleen A.;Chen, Sonia;Sinha, Manisha;Rubin, Lee L.;Wagers, Amy J.
通讯作者：
Wagers, Amy J.
p38alpha/beta MAPK 作为分子开关来激活静止的卫星细胞。
影响因子：
7.8
作者：
Jones, NC;Tyner, KJ;Nibarger, L;Stanley, HM;Cornelison, DDW;Fedorov, YV;Olwin, BB
通讯作者：
Olwin, BB