The effects of mindfulness-based stress reduction on psychosocial outcomes and quality of life in early-stage breast cancer patients: a randomized trial.
The effects of mindfulness-based stress reduction on psychosocial outcomes and quality of life in early-stage breast cancer patients: a randomized trial.
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DOI：
10.1007/s10549-011-1738-1
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发表时间：
2012-01
影响因子：
3.8
通讯作者：
Hebert, James R.
中科院分区：
文献类型：
--
作者：
Henderson, Virginia P.;Clemow, Lynn;Massion, Ann O.;Hurley, Thomas G.;Druker, Susan;Hebert, James R.
关键词：
本研究的目的是使用三臂随机对照临床试验（RCT）确定基于正念的减压（MBSR）计划对早期乳腺癌女性的生活质量（QOL）和心理社会结局的有效性。这项随机对照试验包括172名年龄在20-65岁的I期或II期乳腺癌妇女，包括8周的正念减压疗法，并将其与营养教育计划（NEP）和常规支持性护理（UC）进行比较。在干预后的三个时间点进行随访：4个月、1年和2年。采用标准化、有效的自填式问卷评估心理社会变量。统计分析包括描述性和回归分析，包括163名基线数据完整的女性的意向治疗和事后多变量方法，与NEP、UC或两者相比，随机接受MBSR的女性在QOL和应对结局的主要指标方面有显著改善，包括FACT-B的精神分量表以及应对疾病量表的积极行为应对和积极认知应对增加。在4个月时，导致组间显著对比的次要结果改善有利于MBSR组，包括意义、抑郁、偏执、敌意、焦虑、不快乐和情绪控制。结果在12个月时趋于下降，在24个月时甚至更多，尽管在任何时候，对效果的期望值较低的女性与期望值较高的女性一样稳健。正念减压疗法的干预似乎有利于癌症患者的心理社会调整，超过了常规护理或可靠的控制条件的效果。跨期望水平的影响的普遍性表明，利用这种减压方法作为肿瘤学实践中的补充治疗的潜力。
The aim of this study was determine the effectiveness of a mindfulness-based stress-reduction (MBSR) program on quality of life (QOL) and psychosocial outcomes in women with early-stage breast cancer, using a three-arm randomized controlled clinical trial (RCT). This RCT consisting of 172 women, aged 20–65 with stage I or II breast cancer consisted of the 8-week MBSR, which was compared to a nutrition education program (NEP) and usual supportive care (UC). Follow-up was performed at three post-intervention points: 4 months, 1, and 2 years. Standardized, validated self-administered questionnaires were adopted to assess psychosocial variables. Statistical analysis included descriptive and regression analyses incorporating both intention-to-treat and post hoc multivariable approaches of the 163 women with complete data at baseline, those who were randomized to MBSR experienced a significant improvement in the primary measures of QOL and coping outcomes compared to the NEP, UC, or both, including the spirituality subscale of the FACT-B as well as dealing with illness scale increases in active behavioral coping and active cognitive coping. Secondary outcome improvements resulting in significant between-group contrasts favoring the MBSR group at 4 months included meaningfulness, depression, paranoid ideation, hostility, anxiety, unhappiness, and emotional control. Results tended to decline at 12 months and even more at 24 months, though at all times, they were as robust in women with lower expectation of effect as in those with higher expectation. The MBSR intervention appears to benefit psychosocial adjustment in cancer patients, over and above the effects of usual care or a credible control condition. The universality of effects across levels of expectation indicates a potential to utilize this stress reduction approach as complementary therapy in oncologic practice.
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影响因子：
3.1
作者：
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