An Overview of Anti-Eukaryotic T6SS Effectors.
An Overview of Anti-Eukaryotic T6SS Effectors.
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DOI：
10.3389/fcimb.2020.584751
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发表时间：
2020
影响因子：
5.7
通讯作者：
Valvano MA
中科院分区：
文献类型：
--
作者：
Monjarás Feria J;Valvano MA
VI型分泌系统(T6SS)是一种跨膜多蛋白纳米机器，被许多革兰氏阴性细菌利用，以接触依赖的方式将效应蛋白转移到相邻的原核或真核细胞中。通常，T6SS基因簇编码至少13个保守的核心组件，用于器械组装和其他保守程度较低的附属蛋白和效应器。它的作用就像一个收缩的尾机，由TSSB/C鞘和一个排出的穿刺器组成，该穿刺器由一个Hcp管组成，顶端是VgrG和PAAR蛋白的尖峰复合体。鞘的收缩将管子从细菌细胞推入目标细胞，并导致有毒蛋白质的注射。根据生物体的生态位和多功能性，不同的细菌将T6SS用于特定的角色。效应器既以货物的形式存在(通过与核心组件之一的非共价相互作用)，也以特殊的结构域(融合到结构组件)的形式存在。虽然已经研究了几种抗原核效应物T6SS，但最近的研究导致了特定化的抗真核效应物的数量大幅增加。针对真核细胞，T6SS参与修饰和操纵允许细菌定居、存活和传播的各种细胞过程，包括黏附修饰、刺激内化、细胞骨架重排和逃避宿主的先天性免疫反应。
The type VI secretion system (T6SS) is a transmembrane multiprotein nanomachine employed by many Gram-negative bacterial species to translocate, in a contact-dependent manner, effector proteins into adjacent prokaryotic or eukaryotic cells. Typically, the T6SS gene cluster encodes at least 13 conserved core components for the apparatus assembly and other less conserved accessory proteins and effectors. It functions as a contractile tail machine comprising a TssB/C sheath and an expelled puncturing device consisting of an Hcp tube topped by a spike complex of VgrG and PAAR proteins. Contraction of the sheath propels the tube out of the bacterial cell into a target cell and leads to the injection of toxic proteins. Different bacteria use the T6SS for specific roles according to the niche and versatility of the organism. Effectors are present both as cargo (by non-covalent interactions with one of the core components) or specialized domains (fused to structural components). Although several anti-prokaryotic effectors T6SSs have been studied, recent studies have led to a substantial increase in the number of characterized anti-eukaryotic effectors. Against eukaryotic cells, the T6SS is involved in modifying and manipulating diverse cellular processes that allows bacteria to colonize, survive and disseminate, including adhesion modification, stimulating internalization, cytoskeletal rearrangements and evasion of host innate immune responses.
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影响因子：
3.7
作者：
Douzi B;Spinelli S;Blangy S;Roussel A;Durand E;Brunet YR;Cascales E;Cambillau C
通讯作者：
Cambillau C
影响因子：
6.7
作者：
Cianfanelli FR;Alcoforado Diniz J;Guo M;De Cesare V;Trost M;Coulthurst SJ
通讯作者：
Coulthurst SJ
影响因子：
4.5
作者：
Brunet YR;Zoued A;Boyer F;Douzi B;Cascales E
通讯作者：
Cascales E
影响因子：
5.2
作者：
Boulant T;Boudehen YM;Filloux A;Plesiat P;Naas T;Dortet L
通讯作者：
Dortet L
影响因子：
28.3
作者：
Cherrak, Yassine;Rapisarda, Chiara;Durand, Eric
通讯作者：
Durand, Eric