Is birthweight associated with thyroid autoimmunity? A study in twins.
Is birthweight associated with thyroid autoimmunity? A study in twins.
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出生体重与甲状腺自身免疫有关吗？
DOI：
10.1089/105072502760043440
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
B. Rees
中科院分区：
文献类型：
--
作者：
D. Phillips;C. Osmond;J. Baird;Alison Huckle;B. Rees
虽然广泛的研究表明，一个人的倾向，发展自身抗体甲状腺过氧化物酶（TPOAb）和甲状腺球蛋白（TgAb）有遗传成分，最近的一份报告表明，生长限制在胎儿的生活也可能有助于。因此，我们测量了TPOAb和TgAb在人口为基础的研究双胞胎（44个单合子和91个双合子）出生于1950年和1955年之间谁是通过出生记录在英国伯明翰登记确定。TPOAb和TgAb通过高灵敏度免疫沉淀试验测定，其中分别可检测到0.01 U/mL和0.1 U/mL。在156名女性中的49名（31%）和116名男性中的7名（6%）中发现TPOAb，TgAb值相似（分别为31%和9%）。在28对纯合子中，10对TgAb一致，7对不一致，先证者一致率为74%。TPOAb的一致率相似（64%），高于双卵双胞胎的一致率。单卵双胞胎的TgAb患病率高于双卵双胞胎（30% vs. 17%，p = 0.01）。此外，我们发现，在单卵双胞胎中出生大小不一致的情况下，较小的双胞胎有较高的TPOAb患病率（p = 0.01）。我们的结果表明，遗传因素和早期环境因素都有助于甲状腺自身免疫的易感性。
Although extensive studies have suggested that an individual's predisposition to develop autoantibodies to thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) has a genetic component, a recent report has suggested that growth restriction during fetal life may also contribute. We have therefore measured TPOAb and TgAb in a population-based study of twins (44 monozygous and 91 dizygous) born between 1950 and 1955 who were identified through a registry of birth records in Birmingham, United Kingdom. TPOAb and TgAb were measured by a highly sensitive immunoprecipitation assay in which 0.01 U/mL and 0.1 U/mL, respectively, were detectable. TPOAb were found in 49 of 156 (31%) of women and 7 of 116 (6%) of men with similar values for TgAb (31% and 9%, respectively). Of 28 monozygous pairs, 10 were concordant for TgAb and 7 discordant giving a probandwise concordance rate of 74%. Concordance rates for TPOAb were similar (64%) and were higher than concordance rates in dizygous twins. Monozygous twins had a higher prevalence of TgAb than dizygous twins (30% vs. 17%, p = 0.01). In addition, we found that where there was discordance in birth size within monozygous twin pairs, the smaller twin had a higher prevalence of TPOAb (p = 0.01). Our results suggest that both heritable and early environmental components contribute to the susceptibility to thyroid autoimmunity.
影响因子：
6.6
作者：
Villanueva, R;Greenberg, DA;Tomer, Y
通讯作者：
Tomer, Y